Term
| 4 inputs that can trigger vomiting: |
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Definition
1. stretch-sensitive or chemosensitive afferent vagal afferents (stretched tummy)
2. Direct stimulation of area postrema
3. vesbitular afferents
4. higher cortical centers |
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Term
| What kinds of agents are effective against motion sickness? |
|
Definition
| muscarinic antagonists or H1/M antagonists |
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|
Term
| Scopolamine is what kind of drug? |
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Definition
|
|
Term
| dimehydrinate is what kind of drug? |
|
Definition
|
|
Term
| promethazine is what kind of drug? |
|
Definition
| mixed H1/M receptor antagonist |
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Term
| when you see - setron, think of |
|
Definition
| selective 5HT3 antagonists |
|
|
Term
| sites of action for - setrons? |
|
Definition
| vagal afferents, nucleus of solitary tract, area postrema - 5HT3 antagonist |
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Term
| Name the receptors metoclopramide agonizes and antagonizes |
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Definition
D2-R antagonist, 5HT3 R antagonist (high dose)
5HT4 R agonist (prokinetic property) |
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Term
| What side effect can chronic use of metoclopramide result in? (think of receptors antagonized...) |
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Definition
|
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Term
| chlorpromazine blocks what kind of receptor? |
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Definition
| DA, so even though it's a classical antipsychotic, it can also be used for post-op nausea |
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|
Term
| prochlorperazine is what kind of drug? |
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Definition
| phenothiazine (such as chlorpromazine) with DA R antagonist activity |
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Term
| What glucocorticoid can enhance the effectiveness of other anitemetics in cancer patients? |
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Definition
|
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Term
| What benzodiazepine can be an adjunt tx for cancer chemotherapy to reduce stress and anticipatory emesis? |
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Definition
|
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Term
|
Definition
| substance P receptor antagonist that is useful for delayed phase vomiting caused by cisplatin |
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|
Term
| Dronabinol is what kind of drug? |
|
Definition
|
|
Term
|
Definition
| stimulate appetite in AIDS patients |
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