# Shared Flashcard Set

## Details

Pharmacology
pharmacokinetics
18
Chemistry
09/17/2006

Term
 IBW equation
Definition
 50 + (2.3 x Height in Inches over 60)45 + (2.3 x Height in Inches over 60)
Term
 ABW equation
Definition
 ABW=IBW + 0.4 (TBW – IBW)
Term
 BSA m2 equation
Definition
 square root of ht(cm)x Wt(kg)/3,600
Term
 what equation is used to calculate the CrCl ml/min?
Definition
 Cockcroft-Gault equation(140-age)(Wt Kg)/(72)(SrCr mg/dl)
Term
 What are the normal values for CrCl in men and women
Definition
 Normal CrCl 97-137 ml/min males 88-128 ml/min femalesRenal dysfunction<60ml/min
Term
 What is the normal creatinine levels in men and women
Definition
 Normal creatinine in men 0.8 to 1.3 mg/dl and in women: 0.6 to 1.0 mg/dl.
Term
 What is the Volume of Distribution equation
Definition
 Vd L = dose/ C0 or Cl/K
Term
 The elimination rate constant equation
Definition
 -K = ln(C1/C0)/t1-t0
Term
 Half-life equation
Definition
 t ½ hr= 0.693/KdOrt ½ hr= (0.693)(Vd)/Cl
Term
 What is the SS Steady State?
Definition
 Point at which, after multiple doses, amount of drug administered over a dosing interval equals amount of drug being eliminated over that same period
Term
 Which body weight should you use to calculate CrCl
Definition
 IBW unless the person is OBESE, then use the adjusted body weight
Term
 what's the criteria for being obese
Definition
Term
 What can you say about a drug that has a high Vd(L)
Definition
 the drug is lipophillic
Term
 What can you say about a drug that has a low Vd(L)
Definition
 the drug is hydrophillic
Term
 if you double the dose and the concentration doubles, what order drug is it?
Definition
 1st order
Term
 describe 1st order drugs
Definition
 The fraction of the drug eliminated is constant
Term
 Describe Zero order drugs
Definition
 The AMOUNT of Drug eliminated over time is constant
Term
 What is CrCl and indicator of?
Definition
 of how well your kidneys are working
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