CLASS I

QUINIDINE

LITTLE EFFECT ON REPOLARIZATION

BETA-ADRENERGIC BLOCKAGE

BETA ADRENERGIC BLOCKADE

BETA ADRENERGIC BLOCKADE

CALCIUM CHANNEL BLOCKER

MISC

MAGNESIUM SULFATE

IA EFFICACY

Class IC Efficacy

Av Nodal reentry

WPW-related arrythmia- Efficacy

Ventricular arrythmia ( can increase mortality despite suppression PVCs)

Efficacy

Atrial Fibrillation/flutter

(ventricular arrythmias)

Class

Atrial fibrillation/ flutter

Ventricular arrythmias

Atrial fibrillation/ flutter

atrial automaticities

AV nodal reentry

AV Node reentry

orthodromic tachycardia

Class

Digitalis Efficacy

AV node reeentry

Atrial fibrillation/ flutter

Torsades de pointes

Class

CLASS TOXICITY

I

PROARYTHMIC EFFECTS

CLASS II TOXICITY

SINUS BRADYCARDIA

AV BLOCK

DEPRESSION OF LV FUNCTION (ADRENERGIC DEPENDENT)

CLASS III TOXICITY

SINUS BRADYCARDIA

TORSADES DE POINTES

CLASS IV TOXCICIY

SINUS BRADCARDIA

AV BLOCK

NEGATIVE INOTROPIC EFFECT

EFFECT ASSOCATED WITH INCREASE MORTALITY

FLECAINIDE

EFFECT ASSOCIATED WITH REDUCES MORTALITY

BETA-ADRENERGIC BLOCKER (PROPANOLOL, TIMOLOL, METOPROLOL) SOTALOL

INADEQUATE DATA

INADEQUATE DATE

INADEQUATE DATA

GI DISTRURBANCE 30-50%

CINCHINISM

HYPOTENSION

ELEVATION OF SERUM DIGOXIN CONCENTRATIONS, RESULTING IN DIGITALIS TOXICITY

HYPERSENSITIVITY REACTIONS

REVERSIBLE THROMBOCYTOPENIA

QUINIDINE (ia)

HYPOTENSION- DUE TO ALPHA ADRENERGIC BLOCKING ACTIVITIES

LONG TERM USE- LUPUS LIKE SYNDROME 15-30 PERCENT-ATHRALGIA AND ARTHITIS(PLEURITIS, PERICARDITIS, PARENCHYMAL PULMONARY DISEASE)

CNS-GIDDINESS, PSYCHOSIS, DEPRESSION HALLUCINATIONS

HYPERSENTSITIVITY REACTIONS-rAYNAUDS VASCULITIS

LOWEST INCIDENCE OF TOXICITY OF CURRENTLY USED ANTIARRYTHMIC DRUGS

CNS DEPRESSION

STIMULATION TINNITIS

MEX AND TOCAIN TOXICITY

LIDOCAINE (Ib)

TREMOR

AGRANULOCYTOSIS

BONE MARROR DEPRESSION- DEATH

USE WITH QUINIDINE LOWERS SIDE EFFECTS

TOCAINANIDE (IB)

MEXILETINE

AMIODARONE (iii)

ADVERS EFFECTS ARE COMMONE SEE THE HAND OUT

HALF LIFE IS 25-110

NON-CARDIAC- ANOREXIA NAUSIA, VOMITING

ABNORMAL VISION

ADENSOSINE (MISC)

SHORT HALF LIFE IN THE BLOOD  (LESS THAT 10 SECONDS)

HYPOTENTION, FLUSHING 20 PERCENT

TRANSIENT DYSPNEA, CHEST DISCOMFORT NON MYOCARDIAL IN 10%

METALLIC TASTE

PARESTHISIAS

Captopril

Ace inhibitor

ace inhibitor

lotensin

Ace inhibitor

vasotech

ace inhibitor

monopril

prinivil, zestril

Ace inhibitor

univasc

ace inhibitor

ace inhibitor

aceon

ace inhibitor

accupril

ACE

Altace

ACE

Mavik

Angiotensin Receptor blocker

Atacand

ARB

Teveten

ARB

Avapro

ARB

COZAAR

OLMESARTAN

ARBS

BENICAR

TELMISARTAN

ARB

MICARDIS

ARB

DIOVAN