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pharmacology
anti-inflammatory drugs
20
Nursing
Undergraduate 2
10/05/2014

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Cards

Term
cardinal signs of inflammation
Definition
erythema, oedema, heat, pain and loss of function
Term
two phases of inflammation and time frames of each
Definition
1) vascular: occurs after 10-15 minutes
2) delayed
Term
cyclooxygenase (COX)
Definition
enzyme responsible for converting arachidonic acid into prostaglandins and their products
Term
COX-1 function
Definition
protects stomach lining and regulates blood platelets
Term
COX-2 function
Definition
triggers inflammation and pain
Term
pyrogens
Definition
products causing fever as they interfere with the hypothalamus thermostat
Term
another name for anti-inflammatory drugs
Definition
prostaglandin inhibitors
Term
effects of anti-inflammatories
Definition
inhibit biosynthesis of prostaglandin, pain relief (analgesic), reduce elevated body temperature (antipyretic) and inhibit platelet aggregation (anticoagulation)
Term
action of NSAIDs
Definition
inhibit biosynthesis of prostaglandin
Term
primary use of NSAIDs
Definition
relieve inflammation and pain
Term
name 2 OTC NSAIDs
Definition
Ibuprofen (Motrin or Advil) and naproxen (Aleve)
Term
Name the 6 groups of first generation NSAIDs
Definition
1) salicylates
2) para-chlorobenzoic acid derivatives, or insoles
3) phenylacetic acids
4) propionic acid derivatives
5) fenamates
6) oxicams
Term
name the group that is a second generation NSAIDs
Definition
selective COX-2 inhibitors
Term
which NSAID group is aspirin
Definition
first generation: salicylates
Term
name 3 things that should not be consumed with aspirin
Definition
other NSAIDs, alcohol, diflunisal (silicate derivative) and various foods containing salicylates
Term
advantage of COX-2 inhibitors
Definition
do not effect stomach lining
Term
3 foods containing salicylates
Definition
raisins, prunes, licorice and spices (paprika, curry powder etc..)
Term
2 contraindications of aspirin
Definition
children less than 12 and elevated fever
Term
which condition may develop as a result of taking aspirin with fever
Definition
risk of developing Reye's syndrome (neurologic problems associated with taking aspirins for viral infections)
Term
CONT'd....
Definition
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