Term
|
Definition
| rapid delievery, 100% of does is absorbed, bolus and finusion control blood levels of drug |
|
|
Term
| intravenous disadvantages |
|
Definition
| invasive, overdose more toxic and difficult to correct |
|
|
Term
|
Definition
| 100% of dose is absorbed, gradual release from injection site |
|
|
Term
| intramuscual disadvantages |
|
Definition
| invasive, inconsistent distribution over time |
|
|
Term
|
Definition
| prolonged delivery, works well for smaller lipophilic drugs |
|
|
Term
| subcutaneous disadvantages |
|
Definition
| does not work well for larger, polar drugs, inconsistent distribution over time |
|
|
Term
|
Definition
|
|
Term
|
Definition
| many drugs broken down in digestive tract and liver, delivery rate and amount affected by food |
|
|
Term
|
Definition
| what the body does to the drug |
|
|
Term
| metabolism/ biotransformation |
|
Definition
| enzymatic alteration of drug structure |
|
|
Term
|
Definition
| takes place in liver- performed by the hepatic microsomal enzyme system- 450 system |
|
|
Term
|
Definition
glomerular filtration
passive tubular reabsorption
active tubular secretion |
|
|
Term
| factors modifying renal drug exretion |
|
Definition
ph-dependent ionization
competition for active tubular transport
age |
|
|
