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Pharmacology
Anti-Inflammatory Agents
29
Health Care
Graduate
08/01/2007

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Cards

Term
Inflammation is a _______ response to tissue injury caused by physical trauma, noxious chemicals or microbiologic agents
Definition
Normal, Protective
Term
_______ is the body’s effort to inactivate or destroy invading organisms, remove irritants and set the stage for tissue repair
Definition
Inflammation
Term
Inflammation usually _______ when healing is complete.
Definition
Subsides
Term
Inflammatory responses are defense mechanisms are capable of causing _______ tissue injury
Definition
Progressive
Term
Mediators of inflammation include _______, _______, _______, and _______.
Definition
Lipids; Amines; Small peptides; Large peptides
Term
Two lipids which are mediators of inflammation are _______ and _______.
Definition
Prostaglandins; Leukotrienes
Term
The primary amine involved in inflammation is _______.
Definition
Histamine
Term
The small peptide involved in inflammation is _______, while the large peptide is _______.
Definition
Bradykinin; Interleukin-1
Term
Prostaglandins are _______, they are made at the site at which they create their effects.
Definition
Autocrine
Term
Prostaglandins _______ circulate in the blood in significant quantities.
Definition
Do NOT
Term
Prostaglandins are _______ to inactive products at their site of action.
Definition
Rapidly metabolized
Term
Prostaglandins are Produced in minute quantities by _______.
Definition
All tissues
Term
Prostaglandins act _______, on tissues where they are produced.
Definition
Locally
Term
Prostaglandins are released in _______ or _______ processes.
Definition
Allergic; Inflammatory
Term
Many NSAIDs work by inhibiting synthesis of _______.
Definition
Prostaglandins
Term
NSAIDS inhibit _______ but not _______ enzymes.
Definition
Cyclooxygenase; Lipoxygenase
Term
_______ is constitutive, while _______ is inducible and associated with inflammation
Definition
COX-1; COX-2
Term
Side-effect of _______ inhibition is inability to form stomach protecting prostaglandins.
Definition
COX-1
Term
NSAIDs have differing _______ , _______ and _______ activities
Definition
Antipyretic; Analgesic; Anti-Inflammatory
Term
Aspirin _______ inactivates cyclooxygenase.
Definition
Irreversibly
Term
Aspirin is rapidly deacetylated by esterases to form _______.
Definition
Salicylate
Term
What drug has antipyretic/anti-inflammatory effects due to blockade of prostaglandin synthesis at the thermoregulatory centers in the hypothalamus and at peripheral target sites?
Definition
Aspirin
Term
Aspirin _______ induce remission in Arthritis.
Definition
Does NOT
Term
Aspirin and other salicylates are _______ than opioids in pain with inflammation involved.
Definition
Better
Term
Aspirin causes _______ and sweating to help dissipate heat in febrile patients.
Definition
Peripheral Vasodilation
Term
Aspirin has _______ effect on normal body temperature.
Definition
NO
Term
Aspirin in higher doses works on the respiratory center in medulla causing _______ and respiratory _______ usually compensated for by the kidneys.
Definition
Hyper ventilation; Alkalosis
Term
toxic levels of Aspirin and other Salicylates produce _______.
Definition
Central Respiratory Paralysis
Term
Prostacyclin _______ gastrin secretion.
Definition
Inhibits
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