Term
| Early Immunosuppresant drugs were _______ and were _______. |
|
Definition
| Glucocorticoids; Nonselective |
|
|
Term
Expansion of activated T cells and
Formation of antibodies through interference with B cell conversion to plasma cells are the MOA of _______. |
|
Definition
|
|
Term
| T-cell inhibitors are _______. |
|
Definition
|
|
Term
| Adrenocorticoids are _______. |
|
Definition
|
|
Term
| _______ is an example of an Adrenocorticoid, which belong to the _______. |
|
Definition
| Prednisone; T-cell inhibitors |
|
|
Term
| Muromonab-CD3 is an _______. |
|
Definition
|
|
Term
| _______ is an antigen receptor blocker |
|
Definition
|
|
Term
| Both Cyclosporine and Tacrolimus are _______. |
|
Definition
| T-Cell activation Blockers |
|
|
Term
| Two T-cell activation blockers are _______ and _______. |
|
Definition
|
|
Term
| Basiliximab (Simulect )and Daclizumab (Zenapax ) are both _______. |
|
Definition
|
|
Term
| Two IL-2 Receptor blockers are _______ and _______. |
|
Definition
|
|
Term
|
Definition
|
|
Term
| _______ is an IL-2 Response Blocker. |
|
Definition
|
|
Term
| Azathioprine and Mycophenolate Mofetil are both _______. |
|
Definition
|
|
Term
| Two Cell Cycle Inhibitors are _______ and _______. |
|
Definition
| Azathioprine; Mycophenolate Mofetil |
|
|
Term
| Sirolimus is also known as _______. |
|
Definition
|
|
Term
| Two early immunosuppressant drugs were _______ and _______. |
|
Definition
|
|
Term
| _______ is the mainstay for preventing rejection in transplantation and Auto-Immune Disorders |
|
Definition
|
|
Term
| If taken systemically over 6 months, Prednisone can cause _______. |
|
Definition
|
|
Term
| Glucocorticoids such as prednisone are said to be _______, because they stimulate the release of glucose. |
|
Definition
|
|
Term
| Although the primary adverse effect of glucocorticoids is Diabetogenesis, they can also cause _______, _______ and _______. |
|
Definition
| Hypertension, Hypercholesterolemia and Cataracts |
|
|
Term
| _______ is a Murine monoclonal antibody against glycoprotein CD3 antigen of human T cells. |
|
Definition
|
|
Term
| _______ is used for Acute allograft rejection in renal, cardiac and hepatic transplants. |
|
Definition
|
|
Term
| _______ is used for bone marrow suppression prior to transplantation |
|
Definition
|
|
Term
| To prevent release of prostaglandins give prednisolone, diphenhydramine (benedryl) to prevent histamine release before administration of _______. |
|
Definition
|
|
Term
| _______ Bind to the surface of circulating T lymphocytes causing phagocytosed lymphopenia & impaired T-cell responses. |
|
Definition
|
|
Term
| Antibodies can be formed against Antihymocyte Antibodies causing _______, _______, and _______. |
|
Definition
| Decreased WBC; Decreased Platelets; Skin Rashes |
|
|
Term
| _______ is a peptide lsolated from a fungus |
|
Definition
|
|
Term
| _______ Inhibits cell mediated immune reactions. |
|
Definition
|
|
Term
| This drug is commonly thought of as the savior of the transplant world. |
|
Definition
|
|
Term
| Humoral Immunity is _______ with Cyclosporine. |
|
Definition
|
|
Term
| _______ inhibits production & subsequent release of IL-2 & inhibits IL-2-induced activation of resting T-cells |
|
Definition
|
|
Term
| Cyclosporine is generally NOT given orally due to _______. |
|
Definition
| Variable absorption from the Gut |
|
|
Term
| Cyclosporine is usually administered in combination with _______ to increase effectiveness. |
|
Definition
|
|
Term
| _______ is used for Prevention of rejection of allogeneic transplanted kidney, liver, heart, and to treat Severe Active RA. |
|
Definition
|
|
Term
| _______ is typically favoured over cyclosporine. |
|
Definition
|
|
Term
| With use of _______, Lower doses of glucocorticoids can be used, reducing the likelihood of infection |
|
Definition
|
|
Term
| The Adverse effects of Tacrolimus are _______, _______ and _______. |
|
Definition
| Nephrotoxicity; Neurotoxicity; Type-I Diabetes (post-transplant) |
|
|
Term
| Tacrolimus shows decreased episodes of rejection than when _______ is used. |
|
Definition
|
|
Term
| Tacrolimus Has the same MOA and Uses as _______. |
|
Definition
|
|
Term
| The Adverse effects of IL-2 receptor blockers are mainly _______. |
|
Definition
|
|
Term
| The _______ adverse effects are Hyperlipidemia, Nephrotoxicity, Headache, nausea and diarrhea. |
|
Definition
|
|
Term
| Sirolimus, a IL-2 Response Blocker, is used after _______. |
|
Definition
|
|
Term
| Generally the adverse effects of Sirolimus are _______. |
|
Definition
|
|
Term
| Azathioprine is a _______. |
|
Definition
|
|
Term
| With _______, Lymphocytes predominantly are affected due to their rapid proliferation and dependence on de novo synthesis of purines required for cell division. |
|
Definition
|
|
Term
| _______ Has little effect on secondary immune response. |
|
Definition
|
|
Term
| _______ is used in Adjunct with other agents in prevention of rejection of solid organ transplants. |
|
Definition
|
|
Term
| _______ is used in treatment of Severe Active RA that is unresponsive to other agents. |
|
Definition
|
|
Term
| The Adverse effects of _______ are fever, chills, N/V, anorexia, diarrhea, pancytopenia, secondary infection |
|
Definition
|
|
Term
| Azathioprine is _______ in pregnancy. |
|
Definition
|
|
Term
| Azathioprine Demonstrates Increased toxicity with _______, necessitating decreased dose of azathioprine. |
|
Definition
|
|
Term
| Immunosuppressants are not to be given concurrenly with _______. |
|
Definition
|
|
Term
| Mycophenolate mofetil has the same MOA as _______. |
|
Definition
|
|
Term
| Pain, diarrhea, spesis, lymphoma are all adverse effects of _______. |
|
Definition
|
|
Term
| Concomitant administration with antacids containing Magnesium or aluminum or cholestyramine decrease absorption of _______. (they act like a sponge) |
|
Definition
|
|
Term
| Mycophenolate mofetil blocks the synthesis of _______. |
|
Definition
|
|
Term
| _______ Deprives rapidly proliferating T and B cells of GMP. |
|
Definition
|
|
