Term
| Postganglionic nerve choices |
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Definition
sympathetic nerve
parasympathetic nerve
ANS effectors: muscle/glands
Parasympathetic M
Skeletal muscle: motor end plate (N) |
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Term
| M1-M5 are classified as what? |
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Definition
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Term
| What are gastric parietal cells-HCL-activates PLC-secretion |
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Definition
|
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Term
| cardiac and smooth muscle cells |
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Definition
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Term
exocrine glands
smooth muscle cells
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Definition
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Term
| What is the exception for postganglionic nerve? |
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Definition
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Term
| What are the two types of cholinergic agonists |
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Definition
direct acting
indirect acting |
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Term
|
Definition
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Term
|
Definition
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Term
| what are the two types of indirect acting cholinergic agonists |
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Definition
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Term
| What type of drugs acts on receptors that are activated by ACH? |
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Definition
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Term
| Direct acting cholinergic agonists general toxic effects |
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Definition
flushing
sweating
bradycardia
bronchoconstriction
GI distress
belching
NVD
miosis
accommodation
salivation
sensation of tightness of urinary bladder (due to contraction) |
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|
Term
anticholinesterase agents (organophosphates)
general toxic effects |
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Definition
miosis
salivation
sweating
bronchial constriction
VD
convulsons
coma |
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Term
| Direct acting cholinergic agonists |
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Definition
acetylcholine
betahenchol
carbachol
pilocarpine |
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Term
| Which parasympathomimetic cannot cross the membrane and is quickly destroted by acetylcholinesterase so it has limited clinical use? |
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Definition
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Term
| Which cholinergic agonist was designed NOT to be destroyed by acetylcholinesterase? |
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Definition
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Term
| What is the duration of action of bethanechol? |
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Definition
|
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Term
| what is the mechanism of action of bethanechol? |
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Definition
| contraction of bladder detrusor and relax sphincter |
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Term
| what are the indications of bethanechol? |
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Definition
| urinary retention after surgeroy or postpartum |
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Term
| A person has sweating, salivation, flushing, decreased blood pressure, nausea, abdominal pain, diarrhea, and bronchospasm...who did it? |
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Definition
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Term
| Whose contraindications are physical obstrution, asthma, and peptic ulcers? |
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Definition
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Term
| how can bethanechol be given? |
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Definition
| oral tablets and injection for subq |
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Term
| Which drug is considered as a third-line agent when other agents are not effective? |
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Definition
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Term
| whose mechanism of action of CV & GI but has dangerous CV effects? |
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Definition
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Term
| which cholinergic agonist is only used typically as a miotic to decrease IOP- glaucoma? |
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Definition
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Term
| Which cholinergic agonist can stimulate both muscarinic and nicotinic receptors at PNS/SNS? |
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Definition
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Term
| Which drug can stimulate Epi release from adrenal medulla? |
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Definition
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Term
| which drug is more resistant to cholinesterase than pilocarpine? |
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Definition
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Term
| Which cholinergic agonists MOA is contraction of ciliary muscle attached to the trabecular meshwork to enhance aqueous humor outflow? |
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Definition
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|
Term
Which drugs indications are glaucoma- IOP decreases in 1 hour
DOC for EMERGENCY lowering of both wide and narrow angle glaucoma? |
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Definition
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Term
| A patient has CNS disturbances; miosis with decreased vision and brow aches that are not related to a decrease in IOP...who did it? |
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Definition
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Term
| What is another name for reversible cholinesterase inhibitors (anticholinesterases) |
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Definition
| indirect cholinergic agents |
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Term
| Do reversible cholinesterase inhibitors cause muscarinic or nicotinic stimulation? |
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Definition
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Term
| Where does acetylcholinestrase cleave ACH to acetate and choline? |
|
Definition
in the pre and post -synaptic/junctional cleft
this prolongs duration of endogenous ACH |
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Term
| Whose mechanism of action is to prolong duration of ACH by binding with acetylcholineserase? |
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Definition
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Term
| whose clinical indication is diagnosis of myasthenia gravis? |
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Definition
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Term
| Who is more rapidly absorbed and has a shorter duraction of action than neostigmine? |
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Definition
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Term
| Which reversible indirect agonist is a tertiary amine and can enter CNS? |
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Definition
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Term
| Which drug's indication is atony which increases intestinal and bladder motility, glaucoma,and tx for anticholinergic overdose? |
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Definition
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Term
| What are some anticholinergic overdoses that are treated with physostigmine? |
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Definition
atropine
tricyclics
phenothiazines |
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Term
| Pt comes in and displays vomiting, salivation, bradycardia, and respiratory arrest...who did it? |
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Definition
| physostigmine with systemic use |
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Term
| Which reversible cholinergic agonist can enter CNS and may cause convulsions in high dose? |
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Definition
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Term
| Whose MOA is anticholinesterase agent that does not enter CNS? |
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Definition
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Term
| which drug's clinical indication is antidote for neuromuscular blockers and myastenia gravis? |
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Definition
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Term
| pt comes in and displays salivation, flushing, decreased BP, and diarhhea...who did it? |
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Definition
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|
Term
| Which reversible indirect cholinergic agonist has the longest duration? |
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Definition
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Term
| which drug's clinical indication is for myasthenia gravis treatment due to longer duration than neostigmine? |
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Definition
pyridostigmine
also has fewer side effects |
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Term
| If a patient overdoses on pyridostigmine they might have... |
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Definition
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Term
| Which drugs actions are miosis, muscle paralysis, respiratory arrest, and convulsions? |
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Definition
echothiophate
why is is only used in the eye - systemic effects are bad |
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Term
| Which drugs clinical indication is irreversible anticholinesterases used to treat glaucoma? |
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Definition
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Term
| Most used anticholinesterase agent? |
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Definition
echothiophate
side effect similar to pilocarpine |
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Term
| What are the four drugs that are not autonomic nerve system drugs and they work on the CNS to treat mild to moderate alzheimers? |
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Definition
tacrine
donepezil
galantamine
rivastigmine |
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Term
| Which drugs MOA is to increase cerebral concentrations of ACH by inhibiting acetylcholinesterase? |
|
Definition
the alzheimer drugs
tacrine
donepezil
galantamine
rivastigmine |
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