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Pharmacology
PPT 5 equations for test
21
Pharmacology
Graduate
06/17/2014

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Cards

Term
use of pharmacokinetic calculations
Definition
determine and adjust drug dosages to achieve desired therapeutic effect
Term
units of Vd
Definition
L/kg
Term
units of dose
Definition
mg/kg
Term
units of Cp
Definition
mg/ml
Term
units of Css
Definition
mg/ml
Term

units of infusion rate

units of rate of elimination

Definition
mg/min
Term
units for clearance
Definition
ml/min
Term
equation for rate of elimination
Definition

Rate of elimination=Cl x Cp

Cp=Dose/Vd

Term
clearance equation
Definition
Cl=rate of elimination/Cp
Term
infusion rate equation
Definition
Infusion rate (dose) = Cl x Css
Term
Css is directly proportional to
Definition
rate of infusion
Term
equation for half life
Definition
t1/2 = 0.693 x Vd/Cl
Term
continuous IV infusion equation
Definition
Css= rate of infusion (dose rate)/ Cl
Term
accumulation factor
Definition
1/fraction lost in one dosing interval
Term
peak steady state equation
Definition
peak stead state concentration=peak concentration (initial) x accumulation factor
Term
peak plasma level equation
Definition
peak plasma level = initial dose/fraction lost
Term
when dosing interval equals the half life the accumulation ratio is always
Definition
2
Term
maintainence dose equation
Definition

MD= Cl x Css

Oral: MD= Cl x Css/ F

Term
loading dose equation
Definition

LD= Vd x Css

Oral LD = Vd X Css / F

Term
Rule of thumb when to check plasma drug concentration?
Definition
before next dose after 2 half lives
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