Term
| drug distribution is dependent on |
|
Definition
blood flow
capillary permeability
drug structure
binding of drug to protein |
|
|
Term
| whic horgans recieve most of the blood flow at first |
|
Definition
|
|
Term
|
Definition
|
|
Term
| drug structure is dependant on |
|
Definition
solubility
electrolyte status
molecular weight |
|
|
Term
| which transport of drugs across biological membranes is influenced by protein binding |
|
Definition
passive
can occur w/ plasma proteins or w/ non-specific tissue proteins |
|
|
Term
|
Definition
weak acids
hydrophobic drugs |
|
|
Term
| alpha1- acid glycoprotein |
|
Definition
|
|
Term
| the fraction of total drug in plasma that is bound is determined by |
|
Definition
drug concentration
affinity for binding sites
number of binding sites |
|
|
Term
at low concentration binding is a function of
at high concentration? |
|
Definition
Kd
binding affinity
@ high=number of sites |
|
|
Term
|
Definition
low dose/capacity
most drugs bound |
|
|
Term
|
Definition
high dose/capacity
mostly free drug |
|
|
Term
| drugs primarily bound to albumin |
|
Definition
bilirubin (I)
sulfonamids(II)
warfarin (I) |
|
|
Term
| drugs binding primarily to a1-acid glycoprotein |
|
Definition
|
|
Term
| drugs binding primarily to lipoproteins |
|
Definition
amitriptyline
nortriptyline |
|
|
Term
|
Definition
not used very much any more for anesthesia
onset and termination of anesthesia rapid
takes forever to excrete
70% accumulation in fat |
|
|
Term
|
Definition
absorbed into the bone
teeth lines |
|
|
Term
| rates of drug movement across the placenta tend to increase |
|
Definition
| twards the term as the tissue laters between maternal blood and fetal capillaries thin |
|
|
Term
| weak bases are passively concentration in |
|
Definition
| the stomach because of the large pH difference |
|
|
Term
|
Definition
hypothetical volume of fluid into which the drug distributes
total amount of drug/concentration |
|
|
Term
|
Definition
large MW
extensive protein binding
Heparin |
|
|
Term
| extracellular fluid compartment |
|
Definition
low MW
hydrophilic
aminoglycosides |
|
|
Term
| intracellular compartments |
|
Definition
low MW
hydrophobic
ethanol |
|
|
Term
| total body water distribution amount |
|
Definition
|
|
Term
extracellular distribution amount |
|
Definition
|
|
Term
| intracellular distibution amount |
|
Definition
|
|
Term
| plasma distribution volume |
|
Definition
|
|
Term
| interstitial volume amount |
|
Definition
|
|
Term
| extracellular breaks into 2 different volumes |
|
Definition
|
|
Term
|
Definition
distribution in absence of elimination
in presence
instantaneous distribution |
|
|
Term
| volume of distribution depends on |
|
Definition
pKa
degree of plasma binding
lipid solubility
binding to other tissues
patient age
gender
disease |
|
|
Term
| drug amount administered = |
|
Definition
|
|
Term
| LOOK AT LAST SLIDE ON DISTRIBUTION PPT |
|
Definition
|
|
