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Pharmacology
Toxicities and SE- Drug reactions by system
44
Pharmacology
Graduate
12/11/2013

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Term
coronary vasospasm
Definition
cocaine, triptans, amphetamines, methamphetamines, ergotamines
Term
cutaneous flushing
Definition
VANC: vancomycin, adenosine, niacin, CCB
Term
dilated cardiomyopathy (cardiotoxicity)
Definition
doxorubicin (adriamycin), daunorubicin
Term
torsades de pointes
Definition
class III (sotalo), class IA (quinidine) antiarrhythimcs, macrocodes, haloperidol, chloroquine, protease inhibitors
Term
agranulocytosis
Definition
Agranulocytosis could certainly cause pretty major damage:
Clozapine, carbamazepine, colchicine, PTU, methimazole, dapsone
Term
aplastic anemia
Definition
chloramphenicol, benzene, NSAIDS, PTU, methimazole
Term
direct coombs-positive hemolytic anemia
Definition
methyldopa
Term
gray baby syndrome
Definition
chloramphenicol
Term
hemolysis in G6PD deficient patients
Definition
INH, sulfonamides, primaquine, ASA, ibuprofen, nitrofurantoin, dapsone, fava beans, naphthalene
Term
megaloblastic anemia
Definition
phenytoin, methotrexate, sulfa drugs, zidovudine
Term
thrombotic complications
Definition
OCPs
Term
thrombocytopenia
Definition
heparin, H2 blockers
Term
cough
Definition
ACEI
Term
pulmonary fibrosis
Definition
BLAB: BLeomycin, Amiodarone, Busulfan
Term
acute chlestatic hepatitis
Definition
erythromycin estylate
Term
focal to massive hepatic necrosis
Definition
halothne, acetaminophen, valproate, amanita phalloides (mushroom toxin)
Term
hepatitis
Definition
INH
Term
pseudomembranous colitis
Definition
clindamycin, ampicillin
Term
adrenocortical insufficiency
Definition
glucocorticoid withdrawal
Term
gynecomastia
Definition
Some Drugs Create Awesome Knockers: spironolactone, digitalis, cimetidine, alcohol use, ketoconazole; also estrogens and marijuana
Term
hot flashes
Definition
tamoxifen, clomiphene
Term
hypothyroidism
Definition
lithium, amiodarone, sulfonamides
Term
hyperglycemia
Definition
niacin, tacrolimus, protease inhibitors
Term
fat redistribution
Definition
glucocorticoids, protease inhibitors
Term
gingival hyperplasia
Definition
phenytoin, verapamil
Term
gout
Definition
furosemide, thiazides, niacin, cyclosporine, pyrazinamide
Term
myopathies
Definition
Fish N CHIPS Give you myopathies: Fibrantes, Niacin, Colchicine, Hydroxychloroquine, IFN-alpha, Penicillamine, Statins, Glucocorticoids
Term
osteoporosis
Definition
corticosteroids, heparin
Term
photosensitivity
Definition
SAT for a photo: sulfonamides, amiodarone, tetracycline
Term
Rash
Definition
bad Rash after a PEC SLAPP: penicillin, ethosuximide, carbamazepine, sulfa drugs, lamotrigine, allopurinol, phenytoin, phenobarbital.
remember: seizures, cillins and sulfas
Term
SLE-like syndrome
Definition
SHIPP: sulfonamides, hydralazine, INH, Procainamide, phenytoin
Term
tndon rupture
Definition
fluoroquinolones
Term
nephrogenic DI
Definition
lithium, democlocycline
Term
Fanconi's syndrome
Definition
tetracycline, heavy metal, Wilsons
Term
Interstitial nephritis
Definition
methicillin, NSAIDS, furosemide
Term
hemorrhagic cystitis
Definition
cyclophosphamide, ifosfamide
Term
SIADH
Definition
carbamazepine, cyclophosphamide
Term
cinchonism (dizziniess, HA, vision change, tinnitus)
Definition
quinidine, quinine
Term
parkinson-like syndrome
Definition
antipsychotics, reserpine, metoclopramide
Term
seizures
Definition
bupropion, imipenem/cilastatin, INH, enflurane, tramadol, metoclopramide, alcohol/benzo withdrawal
Term
tardive dyskinesia
Definition
antipsychotics
Term
antimuscarinic
Definition
atropine, TCAs, H1 blockers, neuroleptics, digoxin, promethezine, amantadine
Term
disulfuram-like reaction
Definition
Crink corona at Midnight and suffer post binge: disulfiram, cephalosporins, metronidazole, sulfonylureas, procarbazine
Term
nephrotoxicity/ototoxicity
Definition
aminoglycosides, vancomycin, loop diuretics, cisplatin
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