Term
|
Definition
| effectiveness in tx psychosis |
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Term
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Definition
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Term
| what type of drug is chlorpromazine? |
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Definition
| first generation antipsychotic |
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Term
|
Definition
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Term
| What receptors does chlorpromazine interact with? |
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Definition
D2 R antagonist (defining property)
alpha 1 antagonist (hypotension & sexual dysfxn)
M antagonist (autonomic side fx)
H1 antagonist (sedation)
non-competitive channel blocker (calcium, sodium, cardiac side fx) |
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Term
| Behavioral and psychological effects of CPZ: early |
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Definition
| "major tranquiling chemical straightjacket": sedation, disinterest for environment, psychomotor slowing, emotional quieting |
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Term
| Behavioral and psychological effects of CPZ: late |
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Definition
| (2-3wks and 4-6 mths to stabilize): alleviates tension, hyperactivity, hostility, hallcuinations & delusions, anorexia, negativism, and sometimes withdrawal |
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Term
| Neurological side effects: chlorpromazine early onset |
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Definition
EPS that are reversible and treatable
Parkinson like sx, akathisia, acute dystonic rxns |
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Term
| Neurological side effects: chlorpromazine late onset |
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Definition
| EPS: tardive dyskinesia (irreversible and untreatable!) |
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Term
| Mechanism of action: chlorpromazine |
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Definition
|
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Term
| Anatomical site of antipsychotic effects: |
|
Definition
| D2 receptors of frontal cortex and limbic structures |
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Term
| Anatomical site of EPS effects: |
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Definition
Early on D2 blockade in the striatum -> inc activity of striatal cholinergic neurons
Later on with TD - TD is not alleviate by anti-muscarinic drugs. Don't know the mechanism. |
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Term
| Side effects: chlorpromazine |
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Definition
| Sedation, coma, lowered seizure threshold, alpha1 blockade, quinidine-like effects on heart , neurleptic malignant syndrome |
|
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Term
| what is neuroleptic malignant syndrome and what is it a side effect of? |
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Definition
A sydnrome of hyperthermia, diffuse muscle rigidity, autonomic sx, altered consciousness
parenterally administered high potency antipsychotics. |
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Term
| how would you treat neuroleptic syndrome? |
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Definition
| as it results from over-suppression of D2, tx muscle rigidity with muscle relaxant and then with bromocriptine the D2 agonist |
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Term
| Thioridazine is what kind of drug? |
|
Definition
| low potency classical antipsychotic |
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Term
| Trifluoperazine is what kind of drug (what level potency)? |
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Definition
| intermediate potency classical antipsychotic |
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Term
| perphenazine is what kind of drug (what level potency)? |
|
Definition
| intermediate, classical antipsychotic |
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Term
| thiothixene is what kind of drug (what level potency)? |
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Definition
| intermediate classical anitpsychotic |
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Term
| haloperidol is what kind of drug (what level potency)? |
|
Definition
| high potency, classical anti-psychotic |
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Term
| Fluphenazine is what kind of drug (what level potency)? |
|
Definition
| high, classical antipsychotic |
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Term
| Sedation and hypotension seen in classical antipsychotics are due to what? |
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Definition
|
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Term
| Why is it that EPS and anticholinergic properties of a gvn classical antipsychotic are inversely related? |
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Definition
| have anticholinergic effects in CNS protects from EPS |
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Term
| Which class of classical antipsychotics show the greatest degree of EPS? |
|
Definition
| high potency b/c no built in anticholinergic |
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Term
| which classical antipsychotic has the smallest degree of EPS? |
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Definition
| Thioridazine (also has the highest anticholinergic effects) |
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Term
| Clozapine is what kind of drug? |
|
Definition
| Atypical 2nd generation antipsychotic |
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|
Term
| Olanzapine is what kind of drug? |
|
Definition
| Atypical 2nd generation antipsychotic |
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|
Term
| Risperidone is what kind of drug? |
|
Definition
| Atypical 2nd generation antipsychotic |
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|
Term
| What is the fatal side effect of clozapine that you have to watch out for? |
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Definition
|
|
Term
| mechanism of action: atypical antipsychotics such as clozapine, risperidone, olanzapine |
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Definition
| D1, D2, D4 blockade + anatogonism of 5HT2A receptors |
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Term
| what differentiates the 2nd generation of antipsychotics from the 1st generation? |
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Definition
| Produce little EPS and may be slightly more effective in tx the negative sx of schizophrenia such as apathy, emotional quieting, loss of insight, poor social interaction) |
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