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| Sites located in the effector cells of muscles and that are acted upon by drugs that stimulate the sympathetic nervous system (adrenergics, adrenergic agonists, or sympathetics). |
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| the chemical structures of a substance that can produce a sympathomimetic response. |
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| Affects different adrenergic receptors |
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| Affects a specific receptor |
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| Drugs that block the effects of adrenergic neurotransmitters |
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| decrease heart rate, and a decrease in blood pressure usually follows |
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| Adrenergic neuron blockers |
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Definition
| Drugs that block the release of norepinephrine from the sympathetic terminal neurons |
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Definition
| Drugs tht block or inhibit a response at the alpha-adrenergic receptor site. |
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Prostate
Eye
Bladder
Blood vessels |
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Definition
Alpha-1 Receptors
Locations: |
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Blood vessels
Smooth muscle |
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Definition
Alpha-2 Receptors
Locations: |
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Definition
Beta-1 Receptors
Locations: |
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Smooth muscle
Uterus
Lungs
Liver |
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Definition
Beta-2 Receptors
Locations: |
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Term
| Adrenergics, adrenergic agonists, sympathomimetics |
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Definition
| Drugs that stimulate the sympathetic nervous system are called _____, _____, or _____ because they mimic the sympathetic neurotransmitters norepinephrine and epinephrine. |
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Definition
| Adrenergic agonists act on one or more adrenergic receptor sites located in the cells of _____. |
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| Postganglionic sympathetic nerve endings, norepinephrine |
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Definition
| Alpha-2 receptors are located in the _____ _____ _____ _____. When stimulated, they inhibit _____. |
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| Myocardial contractility, heart rate |
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Definition
| Stimulation of beta-1 receptors increases _____ _____ and _____ _____. |
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Term
Reuptake back into the neuron.
Enzymatic transformation or degradation.
Diffusion away from the receptor. |
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Definition
| Transmitters are in inactivated by (3 ways)..... |
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Monoamine oxidase (MAO)
Catechol-o-methyltransferase (COMT) |
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Definition
| The two enzymes that inactivate norepinephrine. |
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Inhibiting reuptake.
Inhibiting degradation by enzyme action |
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Definition
| Drugs can prolong the action of the neurotransmitter by....(2 ways) |
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Direct-acting sympathomimetics (directly stimulate the adrenergic receptor)
Indirect-acting sympthomimetics (stimulate the release of norepinephrine)
Mixed-acting sympathomimetics (stimulate adrenergic receptors and stimulate the release of norepinephrine) |
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Definition
| 3 classifications of sympathomimetics. |
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Definition
| The chemical structures of a substance that an produce a sympathomimetic response. |
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| Adrenergic blockers, adrenergic antagonists, sympatholytics |
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Definition
| Drugs that block the effects of the adrenergic neurotransmitter are called....(3 names) |
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Definition
| Useful in treating mild to moderate hypertension, angina pectoris, and myocardial infarction. |
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| Vasculature tissues (vessels) of muscle |
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Definition
| The alpha adrenergic receptors are located in the: |
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Definition
| Dopaminergic receptor can only be stimulated by... |
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| The vessels to dilate and the blood flow increases |
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Definition
| When dopaminergic receptors are stimulated they cause... |
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Definition
| Excites all receptors approximately equally |
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| Strengthens myocardial contractions |
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| Intrinsic sympathomimetic activity (ISA) |
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Definition
| ...is the ability of certain beta blockers to bind with a receptor and exert limited or partial activation of the receptor while preventing strong agonists from binding to that receptor producing complete activation. |
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