Term
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Definition
Loss of neurons in substantia nigra
These neurons release dopamine
Dopamine is inhibitory
Without dopamine, the GABA neurons are being over excited
*lewy bodies |
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Term
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Definition
levodopa - dopamine precursor
carbidopa - decarboxylase inhibitor (periphery)
entacapone - COMT inhibitor (periphery)
talcapone - COMT inhibitor (brain & periphery)
benztropine
amantidine |
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Term
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Definition
Loss of neurons in cerebral cortex & hippocampus (decrease in Ach)
*plaques & tangles |
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Term
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Definition
donepezil (Aricept) - AchEst. inhibitor
rivastigmine (Exelon) - AchEst. inhibitor
memantine (Namenda) - glutamate NMDA antagonist (blocks Ca+ channels) |
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Term
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Definition
ALS/Lou Gehrig's & Huntingdon's
baclofen (Lioresal) |
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Term
Antipsychotic Drugs
(schizophrenia, tourettes, bipolar, psychosis) |
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Definition
dopamine D2 blockers (mesolimbic/mesocortical)
chlorpromazine (Thorzazine)
thiothixene (Navane)
haloperidol (Haldol)
serotonin/5HT blockers (newer)
clozapine (Clozaril)
olanzapine (Zyprexa)
quetiapone (Seroquel)
aripiprazole (Abilify)
ziprasidone (Geodon)
risperidone |
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Term
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Definition
amitriptyline - tricyclic
nortriptyline - tricyclic
fluoxetine - SSRI
escitalopram - SSRI
sertraline - SSRI
paroxetine - SSRI
venlafaxine - SNRI
hydralazine - MAOI
isoniazid - MAOI
buproprion
trazodone
lithium - for bipolar |
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Term
Anxiety Drugs
(panic disorder, post-traumatic stress, OCD, phobias, anxiety) |
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Definition
Benzodiazepines (bind GABA receptors on Cl- channels)
diazepam
lorazepam
oxazepam (Serax)
alprazolam
chlordiazepoxide (Librium)
Others
buspirone - for chronic anxiety (nonsedating/nonaddictive)
propranolol(beta-blockers) |
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Term
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Definition
Benzodiazepine Agonists
zolpidem (Ambien)
zaleplon (Sonata)
eszopiclone (Lunesta)
Melatonin Agonist
ramelteon (Rozerem) |
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Term
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Definition
Na+ or Ca++ channel blockers
phenytoin (Dilantin)
carbamazepine (Tegretol)
lamotrigine (Lamictal)
valproic acid (Depakote)
ethosuximide (Zarontin)
gabapentin (Neurontin)
levetiracetam (Keppra)
oxcarbazepine (Trileptal)
pregabalin (Lyrica)
topiramate (Topamax)
zonisamide (Zonegran)
clonazepam (Klonopin)
phenobarbital
falbamate - lennox gastaut syndrome |
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Term
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Definition
AGONISTS (mu receptors)
morphine
methadone
buprenorphine [partial]
fentanyl
meperidine (Demerol)
pentazocine [kappa]
ANTAGONISTS
naloxone
naltrexone |
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Term
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Definition
ibuprofen (Motrin/Advil)
naproxen (Aleve)
diclofenac
etodolac
nabumetone
piroxicam
oxaprozin
indomethacin
celecoxib (Celebrex) - selective for COX-2 |
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Term
Gout Drugs
(increased uric acid) |
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Definition
colchicine (Colcrys) - anti-inflammatory
allopurinol (Zyloprim) - xanthine oxidase inhibitor
uricosuric's (block reabsorption of uric acid)
probenecid
sulfinpyrazone
Can use NSAIDs, but not aspirin |
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Term
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Definition
Serotonin Agonists
sumatriptan (Imitrex)
other "triptans"
ergotamine |
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