Term
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Definition
9 -> (7+TF) -> 9a
X -> (9a) -> Xa
proThrombin -> (Xa) -> Thrombin
Fibrinogen -> (thrombin) -> Fibrin clot
*fibrin binds platelets and crosslinks them
*cascade is catalytic/amplifiable, NOT stoicheometric (1:1)
*normal aPTT time = 30 sec |
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Term
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Definition
decreased cAMP
thrombin
ADP
TXA2
5HT/serotonin |
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Term
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Definition
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Term
| Half-lives of clotting factors |
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Definition
Factor VII 5 hours
Protein C 6 hours
Factor IX 15 hours
Factor X 1 day
Prothrombin 2-3 days |
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Term
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Definition
class - antithrombin
MOA - huge sugar chain that inhibits thrombin by binding it to antithrombin. also binds factor Xa to antithrombin. it is catalytic bc once it facilitates binding it releases itself and can act again (so it's action is antithrombin dependent).
Increases: LPL (which cleaves TGs)
Decreases: thrombin, fibrin
AE - thrombocytopenia, thrombosis |
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Term
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Definition
class - factor Xa inhibitor (LMWH)
MOA - smaller sugar chain that inhibits factor Xa by binding it to antithrombin. it is also catalytic and antithrombin dependent.
Decreases: factor Xa, thrombin, fibrin
AE - thrombocytopenia, thrombosis |
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Term
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Definition
class - vitamin K reductase inhibitor
MOA - keeps vitamin K in an oxidized state so it can't catalyze the carboxylation of clotting factors which lowers their affinity to Ca+
Decreases: various clotting factors
AE - bleeding, necrosis, pregnancy-X |
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Term
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Definition
class - adenosine receptor inhibitor
MOA - prodrug that prevents ADP from binding to platelets which in turn increases cAMP
where: platelets
Increases: cAMP
Decreases: ADP
AE - thrombocytopenia |
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Term
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Definition
class - PDE(3) inhibitor
MOA - inhibits PDE(3) which converts cAMP
where: platelets
Increases: cAMP
AE - headache |
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Term
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Definition
class - integrin inhibitor
MOA - blocks integrin which is a receptor for fibrinogren on platelets
where: platelets
Decreases: binding/crosslinking
AE - hypersensitivity (mouse part) |
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