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Pharmacology Skeletal Muscle Relaxants
Exam 2
35
Nursing
Not Applicable
03/22/2011

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Term
spasm
Definition
cramp which is a sudden involuntary, painful muscle contraction.

Usually a result of overuse or musculoskeletal injury, sprains, strains, bursitis, arthritis
-clonic = intermittant contraction/relaxation
-tonic = sustained contraction
Term
spasticity
Definition
involve increased muscle tone or contraction and stiff awkward movements

Occurs with spinal cord injury, MS (Multiple Sclerosis)
Term
Multiple sclerosis
Definition
-idiopathic autoimmune disease
-effects more women than men
-demylenation of brain, spinal cord, optic nerve.
Term
demyelination
Definition
occurs when the insulation of nerves is destroyed. This causes slow or blocked nerve impulses.
Term
MS Symptoms
Definition
Loss of balance, Muscle spasms, Numbness or abnormal sensation in any area, Problems moving arms or legs, Problems walking, Problems with coordination and making small movements, Tremor in one or more arms or legs, Weakness in one or more arms or legs

-Constipation and stool leakage, Difficulty beginning to urinate, Frequent need to urinate, Strong urge to urinate, Urine leakage (incontinence)

-Double vision,Eye discomfort, Uncontrollable rapid eye movements, Vision loss

-Facial pain , Painful muscle spasms, Tingling, crawling, or burning feeling in the arms and legs

ETC.

Sexual problems, swallowing, speaking problems, decreased attention span, poor judgement
Term
Stimuli that precipitate spasms
Definition
Muscle stretching,
bladder infxns, stones, constipation (any obstructions can cause spasm).
Term
Stimuli that precipitate spasms
Definition
Muscle stretching,
bladder infxns, stones, constipation (any obstructions can cause spasm).
Term
MS contributing factors
Definition
emotional stress
fatigue
infxns
heat

(heat is almost always a contributing factor for sdisease manifestations. as with chemical processes it speends up rxns)
Term
MS treatments
Definition
Steroids - acute exacerbations
Interferon beta - prevent relapse
Immunosuppressants (methotrexate) - treat progression
Antidepressants
Skeletal muscle relaxants - control spasticity
Term
Malignant hyperthermia
Definition
Complication of anesthesia

-Hypercarbia (too much carbon in blood)
-Metabolic Acidosis
-Skeletal muscle rigidity
-fever
-cyanosis

rare and life threatening
Treated with muscle relaxant
Dantrolene (dantrium)(only works on muscle fiber)
Term
mechanism of skeletal muscle relaxant
Definition
All muscle relaxants except for Dantorlene are centrally active drugs.
They work to depress the CNS.
reduce nerve impulses along fiber.
Term
Contraindications for skeletal muscle relaxant use
Definition
impaired renal func.
impaired kidney func.
respi. depression
Glaucoma
Cardiac dysrhythmias

causes muscle weakness and should not be used with activities requiring alertness/coordination
Term
______ _______ ________ are used to decease muscle spasm or spasticity that occurs in certain neurologic and musculoskeletal disorders.
Definition
Skeletal muscle relaxants
Term
___ ___ or cramp is a sudden, involuntary, painful muscle contraction that occurs with musculoskeletal trauma
Definition
Muscle spasm
Term
Spasm may be ______ (alternating between contraction and relaxation)+

20
Definition
Clonic
Term
Spasm may be ______ (sustained contraction)
Definition
Tonic
Term
_________ involves increased muscle tone or contraction and stiff, awkward movements.
Definition
Spasticity
Term
Used to relieve discomfort from acute, painful musculoskeletal disorders
Definition
metaxalone
Term
An alpha 2 adrenergic agonist, similar to clonidine, that is used to treat spasticity in MS patients, spinal cord injuries, & brain trauma
Definition
Tizanidine
Term
used maily to treat spasticity in MS and spinal cord injuries
Definition
Baclofen
Term
Acts directly on skeletal muscle to inhibit muscle contraction
Definition
Dantrolene
Term
Used to relive discomfort from acute, painful muscloskeletal disorders; also may be used to treat tetanus.
Definition
Methocarbamol
Term
Pathophysiology of MS
Definition
idiopathic, autoimmune destruction of myeline, aka demyelination of nerve fibers in brain spinal cord & optic nerve.
Myelin is need for smooth rapid transmission of impulses along nerve fibers. Without myelin the impulse is slowed or blocked. Can be acute, subacute, or chronic.
Term
Corticosteroids
Definition
potent anti-inflammatory drugs

used to treat acute exacerbations.
Term
Interferon-beta, Glatiramer, & mitoxantrone
Definition
suppress the immune system and are given to prevent relapses
Term
Other drugs (antidepressants, antibiotics, anticonvulsants for neuropathic pain)
Definition
are used to treat symptoms
Term
Skeletal Muscle relaxants
Definition
Dantroline, Baclofen, tizanidine,
Term
Dantrolene, Baclofen,tizanidine
Definition
used to treat spasticity
Term
Dantrolene
Definition
only muscle relaxant that works directly on skeletal muscle. Everyone else gets down with the CNS. -get it, gets down as in depresses CNS.
Term
Why skeletal muscle relaxants?
Definition
When pain impedes progress during physical therapy.
When ADL are impaired do to pain.
When pain impedes sitting in a wheel chair or participating in physical therapy
Term
What to do if you are diagnose with MS?
Definition
enroll in physical therapy to maintain muscle tone. enroll in occupational therapy to maintain ability to perform ADLs.
Term
How to cope with dizziness/confusion brought on by Baclofen?
Definition
Consider what times of day alertness is needed. Since Baclofen acts in 1 hour, peaks in 2 and last 4 to 8 hours consider taking them when mental faculties are being least tested.
Term
Drugs used to treat spasticity with MS are ______ & __________.
Definition
Baclofen & Tizanipine
Term
To treat muscle spasms and spasticity, the dr. may order:
Definition
Occupational & Physical therapy
Term
Baclofen & Tizanidine. Which drug used for spaticity causes fewer side effects
Definition
Tizanidine
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