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Pharmacology Review 3
Psychoactive Rx
6
Health Care
Graduate
11/19/2011

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Cards

Term
Amobarbital
Definition
Barbituates

Sedatives, Hypnotics & AntiEpileptics
General CNS depresants. They impede impulse conduction in the ascending reticular activating system, depress the cerebral cortex, alter cerebellar function, depress motor output, and can produce excitation, sedation, hypnosis, anesthesia, and deep coma. Can have anti-convulsant activity.
--insomnia, pre-anesthetic, seizures
Term
Acebutolol, atenolol
Definition
Beta-Adrenergic Blockers

AntiAnginals, AntiArrhythmics, AntiHypertensives.
Competitively block beta-adrenergic receptors in the heart and juxtaglomerular apparatus. They decrease teh influence of te sympathetic NS on these tissues, The excitability of the heart, Cardiac workload, Oxygen consumption, and release of rennin. They lower BP, have membrane-stabilizing effects (local anesthetic).

--stress induced angina, palpitations, stage fright
Term
AlprazoLAM, DiazePAM
Definition
Benzodiazepines

Anxiolytics, AntiEpileptics, Muscle relaxants, Sedative Hypnotics.
Action is not understood, but it is known that Benzodiazepines potentiate the effects of GABA, an inhibitory neurotransmitter

--Anxiety Disorder, insomnia, seizures, PMS, IBS, alcohol-withdrawal syndrome
Term
citalopram, dapoxetine, fluoxetine, fluvoxamine, paroxetine, sertraline
Definition
Selective Serotonin Reuptake Inhibitors

Antidepressants by inhibiting CNS neuronal uptake of serotonin and blocking uptake of serotonin with little effect on norepinephrine; antagonize muscarinic , histaminergic, and alpha1-adrenergic receptors. The increase in serotonin levels at neurocreceptoes act as a stimulant, counteracting depression and increasing motivation.

--Depression, OCD, PTSD, Social Anxiety, Generalized Anxiety, Panic Diso, PMDD, Obesity, Bulimia
Term
ChlorpromAZINE
Definition
Phenothiazines

Antipsychotic - not fully understood.
blocks postsynaptic dopamine receptors in brain, but this may not be necessary and sufficient for antipsychotic activity.
Depresses the RAS (rennin-angiotensin system), including parts of the brain involved w/wakefulness adn emesis. Anticholinergic, antihistaminic, and alpha-adrenergic blocking activity may also contribute to its effects.

--Psychotic diso, Control of severe nausea/vomiting, intractable hiccups
Term
Amitriptyline
Definition
Tricyclic Antidepressants (TCAs)

Unknown mechanism. Structurally, they are related to phenothiazine antipsychotic drugs, but they inhibit the pre-synaptic re-uptake of norepinephrine and serotonin;
Anticholinergic at CNS and peripheral receptors
--major depressive diso, OCD, Obstructive Sleep Apnea, Panic Diso, Eating Diso, PMS, Migraine, ADHD
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