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Pharmacology Reproduction
Reproduction
17
Bible Studies
11th Grade
05/18/2012

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Term
Testosterone converted to DHT via..
Definition
5alpha reductase
Term
Testosterone and androstendione are converted to estrogen via..
Definition
aromatase
Term
Agonist at androgen receptors
Used to treat hypogonadism, development of 2ndary sex characteristics
Definition
Testosterone (methyltestosterone

toxicity:
masculinization in females, reduces intratesticular testosterone by inhibiting release of LH, gonadal atrophy. closing of epiphyseal plates
Term
Decrease conversion of testosterone to DHT

Used for BPH
Definition
Anti-Androgens:
Finasteride
Dutasteride
Term
Medications to treat BPH
Definition
Finasteride
Dutasteride

Alpha blockers
-Zosins
Term
Non steroidal competitive antagonist to testosterone
Definition
Flutamide
Term
Inhibits steroid synthesis by inhibiting desmolase
Definition
Ketoconazole
Term
Alpha-1 antagonist used to treat BPH that is more selective
Selective more for receptor on the prostate
Definition
Tamulosin

No blood pressure drop
Term
Oral contraception MOA and physiological effects on body
Definition
Drugs that will present the LH surge, ovulation does not occur.
Thin endometrium, thicken
Decrease acne by creating more Sex hormone binding globulin
Term
Binds estrogen receptors

Used for birth control, hypogonadism, menstrual abnormalities, HRT in postmenopausal women
Definition
Estrogens:
ethinyl

Toxicity: risk of endometrial bleed due to unopposed estrogen, clear cell adenocarcinoma of vagina in women exposed to DES.

Increased risk of thrombi especially with women over 35
Term
Mechanism and clinical use of Progesterone
Definition
Mechanism and clinical use of Progesterone

Bind to progesterone receptors
Reduce growth of endometrium
and increase vascularization of endometrium

Used in oral contraceptives and in treatment of endometrial cancer and unapposed endometrial bleeding (anti-estrogen)
Term
GnRH agonist
Definition
Leuprolide

Used continuously: inhibitor
Used pulsatile fashion: stimulation

Toxicity: Menopausal symptoms
Term
Decreases negative feedback of estrogen on Hypothalamus pituitary axis

Induces ovulation
Definition
SERMs:
Clomiphene

A estrogen analog that is a partial agonist that won't give you complete negative feedback like how normal physiologic estrogen would

Toxicity:
Vision changes
Multiple births
Term
Aromatase inhibitor
off label use for ovulation inducer
Definition
Letrozole
Term
PGE analogs for inducing contractions, cervical dilations
Definition
Dinoprostone
Misoprostol
Term
Goes by RU-486
Competitive inhibitor of progestins at progesterone receptors
Definition
Mifepristone
Commonly given with misoprostol (PGE1)

Used for termination of pregnancy.
Term
Commonly used as tocolytics
Definition
Magnesium
Ritodrine
Terbutaline
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