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Pharmacology of Cholernergics
Pretty in-depth set of receptors and indications for cholernergics
66
Pharmacology
Professional
02/02/2011

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Cards

Term
M1 Receptor location
Definition
Nerves
Term
M2 Receptor Location
Definition
Heart
Term
M3 Recepor Locatoin
Definition
Glands, vascular smooth muscles, endothelium
Term
M4 Receptor Location
Definition
CNS
Term
M5 Receptor Location
Definition
CNS
Term
M1 Receptor MOA
Definition
IP3
Term
M2 Receptor MOA
Definition
cAMP
Term
M3 Recptor MOA
Definition
IP3
Term
M4 Receptor MOA
Definition
cAMP
Term
M5 Receptor MOA
Definition
IP3
Term
Muscarinic Agonst Effect on Heart
Definition
Negative chronotropic, ionotropic, dronotropic effects. Vessel dilation, Decreased contraction strength
Term
By what mechanisms does ACh slow the heart?
Definition
Slows spontaneous depolorization rate, increases repolarizing K current in SA node
Term
In which muscles does ACh reduce contractile strength?
Definition
Atrial
Term
Vasodilation occurs because of what?
Definition
M3 agonist stimulation on epithelial cells
Term
What is the effect of muscarinic stimulation on the bladder?
Definition
Emptying. Deltrusser contracts, sphincter relaxes
Term
Muscarinic effect on lungs?
Definition
bronchoconstriction
Term
Pilocarpine is used for what?
Definition
Dry mouth from Sjogren's syndrome
Term
Which muscarinic agonist has nicotinic stimulating effect too?
Definition
Carbochol
Term
Muscarinic effect on eyes?
Definition
pupil constriction and drainage of acqueous humor
Term
Methacoline use
Definition
Diagnosis of asthma
Term
Carbechol use
Definition
glaucoma
Term
Cevemeline stimulates what receptors
Definition
M1 and M3
Term
Contraindications for muscarinie agonists
Definition
Asthma, hyperthyroidim, coronary insufficiency, acid-peptic disease
Term
Muscarinic side effects
Definition
flushing, sweating, abdominal cramp tightness in bladder, difficulty in visual accommadation, headache, salivation
Term
Atropine indication
Definition
Motion sickness, nausea, vomitting
Term
Scopalamine indication
Definition
Motion sickness, nausea, vomitting
Term
Hyoscyamine indication
Definition
Motion sickness, nausea, vomitting
Term
Pirenzepine indication
Definition
Peptic ulcer
Term
methscopalamine indication
Definition
Peptic ulcer
Term
glycopyrrolate indication
Definition
Peptic ulcer
Term
ipratropium indication
Definition
asthma
Term
tiotropium indication
Definition
asthma, copd
Term
oxybutiynin indication
Definition
Urinary tract incontinence
Term
propantheline indication
Definition
Urinary tract incontinence
Term
tolterodine indication
Definition
Urinary tract incontinence
Term
trospium indication
Definition
Urinary tract incontinence
Term
darifenacin indication
Definition
Urinary tract incontinence
Term
solifenacin indication
Definition
Urinary tract incontinence
Term
Trihexyphenidyl indication
Definition
Parkinson's Disease
Term
benztropine indication
Definition
Parkinson's Disease
Term
Ipratropium receptors
Definition
All muscarinic
Term
Tiotropium receptors
Definition
M1 and M3
Term
True or false: Tiotropium and Iptratropium are well absorbed
Definition
False. Their effects are entirely on mouth and lungs
Term
True or False: Tiotropium and Ipratropium are less inhibitory on mucociliar clearance relative to atropine.
Definition
true
Term
Oxybutynin selectivity
Definition
Non-selective muscarine antagonist
Term
propantheline selectivity
Definition
Non-selective muscarine antagonist
Term
tolterodine selectivity
Definition
Non-selective muscarine antagonist
Term
trospium selectivity
Definition
Non-selective muscarine antagonist
Term
darifenacin selectivity
Definition
M3-selective muscarinic antagonist
Term
solifenacin selectivity
Definition
M3-selective muscarinic antagonist
Term
Muscarine antagonist effect on bladder
Definition
relaxatin of detrusor, tightening of sphincter
Term
muscarinic antagonist side effects
Definition
dry mouth, rapid pulse, blurred vision from dilated pupils, difficulty micturating, constipation, restlessness, hallucinations
Term
Contraindication for muscarinic antagonists
Definition
glaucoma
Term
Edrophondium indication
Definition
myasthenia gravis diagnosis
Term
neostigmine indication
Definition
myasthenia gravis, postoperative urinary retention
Term
Neostigmine IV indication
Definition
antidote for curariform poisoning
Term
Physostigmine indication
Definition
glaucoma
Term
pyridostimine indication
Definition
myasthenia gravis or curariform drug antidote
Term
Donepizil indication
Definition
Alzheimer's disease
Term
Why isn't tacrine used anymore?
Definition
Hepatotoxicity
Term
Does donepizil inhibit AChE reversibly?
Definition
yes
Term
Does Rivastigmine inhibit AChE reversibly?
Definition
no
Term
Does galantamine inhibit AChE reversibly?
Definition
yes
Term
What is the only depolarizing NM blocking agent?
Definition
succinylcholine
Term
What NM blocking agent releases the most histamine?
Definition
Tubocurarine
Term
Which NB blocking agent isn't reversed by AChE inhibitors?
Definition
succinylcholine
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