Term
| Mechanism of action of Acid secretion |
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Definition
H+/ATPase in the parietal cells stimulated by
Vagus Nerve --> Ach
Entero Chromaffin Like Cells --> Histamine(H2)
Gastrin --> Calcium
Carbonic anhydrase reaction:
H2CO3 ---> H+ and HCO-
As H+ is secreted in the stomach, HCO3- is absorbed into the plasma, causing a serum alkalosis. |
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Term
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Definition
"-tidine"
Cimetidine
Ranitidine
Famotidine
Nizatidine
Reversible block of H2 Receptor on H+/ATPase
*Cimetidine causes anti-androgenic effects. Causes gynacomastia and decreased libido. Men don't like taking this drug...
inhibitor of P450 |
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Term
| Proton Pump Inhibitors (PPI) |
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Definition
"-prazoles"
Omeprazoles
Lansoprazole
Irreversibly blocks H+/ATPase pump.
Used in PUD, GERD, Gastritis and Zollinger Ellison Syndrome |
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Term
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Definition
Physically binds to ulcer base providing protection
Increases Ulcer Healing
Used in triple therapy in H.Pylori Infection:
Metronidazole
Amoxicillin
Bismuth |
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Term
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Definition
PGE1 analog. Increases production of gastric mucosal barrier.
Used for prevention of NSAID induced PUD.
Contraindicated in women because its also used as an ABORTIFACIENT |
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Term
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Definition
Pirenzepine
Propantheline
Blocks M1 receptors on ECL cells
Blocks M3 receptors on Parietal cells |
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Term
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Definition
Somatostatin Hormone analog. Inhibits all other hormones to stop body functions and causes vasoconstriction
Used for:
Esophageal Varices
Carcinoid Syndrome
Zollinger Ellison Syndrome |
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Term
| Prokinetic/motility Agents |
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Definition
MOA: Must do either of the following
Inc Ach
Inc 5HT
Dec D2
Bethanechol (Cholinergic Agonist)
Neostigmine (Anticholinesterase)
Metoclopramide (Inc 5HT Dec D2)
Domperidone (Dec D2)
Cisapride (Inc 5HT)
Macrolides (stimulates smooth mm)
**Metoclopramide can cause seizures |
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Term
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Definition
5-ASA agents:
Mesalamine
Sulfasalazine
6-Mercaptopurine Analogs:
Azathioprine/mercaptopurine
Anti Dihydrofolate Reductase:
Methotrexate
Anti TNF agents:
Infliximab
Adalimumab
Corticosteroids |
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Term
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Definition
Orlistat
Alters fat metabolism by inhibiting pancreatic lipase. Side effects of steatorrhea, reduced absorption of fat soluble vitamins
Sibutramine
sympathomimetic serotonin and Norepi reuptake inhibitor
Contraindicated in CAD, CHF, arrythmia, SSRI/MAOIs |
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Term
| Treatment for Wilsons Disease |
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Definition
Penicillamine
(Coppers made of pennies) |
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Term
| Treatment for Hemochromatosis |
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Definition
deFERoxamine
Phlebotomy (blood letting)
Classic Triad of Hemochromotosis:
Diabetes, bronzing, micronodular cirrhosis
'FE' just like iron |
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Term
| Drug Cocktail for patients with severe cirrhosis |
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Definition
Propranolol
Lactulose
Diuretics
Antibiotics
Vitamin K
Octreotide |
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Term
| Medications used for Chronic Hepatitis B and C |
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Definition
Alpha-Interferon
Ribaviron
Glycoproteins from human leukocytes that block viral RNA and DNA synthesis. Induces ribonuclease that degrades viral mRNA |
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Term
Medication for Primary Biliary Cirrhosis
and Gall Stones |
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Definition
Ursodiol
Decreases liver synthesis of cholesterol. Decrease intestinal absorption of cholesterol. |
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Term
| Drug to relieve biliary colic |
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Definition
Dicyclomine
Anticholinergic drug, relaxes smooth muscle and relieves symptoms of biliary colic |
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Term
| Treatment for Gallstones with from undercooked fish |
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Definition
Praziquantel
Trematodes (flukes)
Clonorchis sinensis |
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Term
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Definition
Inhibits HMG-CoA reductase
Cholesterol comes from Acetyl Co-A |
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Term
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Definition
Heart benefits to help arrythmia
Nerve development in utero
Reduce inflammation in rheumatic diseases |
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Term
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Definition
|
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Term
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Definition
Caused by ASPRIN usage in a child, associated with infection from VZV/influenza.
Causes childhood hepatoencephalopathy by decreasing B-oxidation in mitochondrial cells |
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Term
| Mineral Compounds used to treat esophageal reflux |
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Definition
Aluminum hydroxide Al(OH)2
Magnesium hydroxide Mg(OH)3
Calcium carbonate CaCO3
Which one causes:
Constipation
Diarrhea
Rebound acid |
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