Term
| what are the 2 other names for psychotherapeutics? |
|
Definition
antipsychotics neuroleptics |
|
|
Term
| why are psychotherapeutics sometimes called neuroleptics? |
|
Definition
| bc they suppress motor activty and emotional expression |
|
|
Term
| what are the 3 phases of a psychotic disorder? |
|
Definition
prodromal acute (positive and negative symptoms) recovery |
|
|
Term
| what are the 3 objectives of psychotherapeutics? |
|
Definition
1. suppression of acute phase 2. prevention of acute exacerbations 3. maintanence of the highest possible level of functioning |
|
|
Term
| psychotherapeutics are used to treat... |
|
Definition
schizophrenia acute mania delusional disorders depressive disorders drug-induced disorders emesis huntington's chloera tourette's |
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|
Term
| what are the 4 types of traditional psychotherapeutics? |
|
Definition
phenothiazines butyrphenones thioxanthines dibenzodiazepines |
|
|
Term
| which phenothiazines are used as antiemetics? |
|
Definition
prochlorperazine promethazine |
|
|
Term
| besides being an antiemetic what else is promethazine used for? |
|
Definition
|
|
Term
| which drug is the prototype for traditional psychotherapeutics? |
|
Definition
|
|
Term
| chlorpromazine can be used as... |
|
Definition
an adjunct in pain relief for intractable hiccups |
|
|
Term
| which psychotherapeutic can be used to treat intractable hiccups? |
|
Definition
|
|
Term
| what are the phenothiazine drugs? |
|
Definition
chlorpromazine prochlorperazine promethazine fluphenazine thioridazine perphenazine |
|
|
Term
| which 2 traditional psychotherapeutics come in a depot formulation? |
|
Definition
|
|
Term
| which drug is a butyrophenone? |
|
Definition
|
|
Term
| what can you use haloperidol for? |
|
Definition
sedation alcohol-induced psychoses Huntington's chlorea Tourette's |
|
|
Term
| what is the MOA of traditional psychotherapeutics? |
|
Definition
block the DA receptor (DA1-5) greater effect on D2 in the mesolimbic system to varying degrees blocks ACh, SE, NE and histamine receptors |
|
|
Term
| what are the 4 main SEs of traditional psychotherapeutics? |
|
Definition
1. acute dystonia: sev. spasms, dev in first few days 2. pseudoparkinsonism: devs in the first month 3. akathsia:pacing and squirming, dev in 1-2 mths 4. tardive dyskinesia: 20%, irreversible, writhing involuntary movements |
|
|
Term
| what drugs can be used to treat akathsia? |
|
Definition
anticholinergics Beta Blockers Benzos |
|
|
Term
| Other AEs of traditional psychotherapeutics |
|
Definition
Neuroleptic malginancy syndrome: lead pipe rigidity, fever, sweating, urinary/fecal incontinence, autonomic instability agranulocytosis anticholinergic effects dermatologic effects neuroendocrine effects orthostatic hypotension sedation seizures sexual dysfunction |
|
|
Term
| are highly sedating drugs more effective at calming agitated patients than less sedating drugs? |
|
Definition
|
|
Term
| are less sedating drugs more effective at treating withdrawn patients than more sedating drugs? |
|
Definition
|
|
Term
| how are traditional psychotherapeutics metabolized? |
|
Definition
|
|
Term
| Do traditional psychotherapeutics cause tolerance and physical dependence? |
|
Definition
yes - tolerance little to no - physical dependence |
|
|
Term
| what are the atypical psychotherapeutics? |
|
Definition
aripiprazole clozapine olanzepine paliperidone quetiapine risperidone ziprasidone |
|
|
Term
| which atypical psychotherapeutic causes agranulocytosis and must be monitored by biweekly CBCs? (it also has a higher incidence of seizure) |
|
Definition
|
|
Term
| is risperidone, olanzepine or clozapine more potent? which has the most EPRs? |
|
Definition
potency risperidone and olanzepine then clozapine least to greatest EPRs clozapine, then olanzepine then risperidone |
|
|
Term
| which atypical psychotherapeutics are similar to each other? |
|
Definition
| risperidone and quetiapine |
|
|
Term
| which 2 atypical psychotherapeutics have a SE of prolonged QT intervals? |
|
Definition
| risperidone and ziprasidone |
|
|
Term
| which atypical psychotherapeutic has been approved for use in schizophrenic 13-28 yos and bipolar 10-18 yos? |
|
Definition
|
|
Term
| what is olanzepine used for? |
|
Definition
psychosis acute mania maintanence of bipolar |
|
|
Term
| which atypical psychotherapeutic causes altered glucose metabolism, DM, inc. appetite and wt gain? |
|
Definition
|
|
Term
| which drug is the major active metabolite of risperidone? |
|
Definition
|
|
Term
| which atypical psychotherapeutic has a black box warning for increased mortality in elderly pts with dementia-related psychosis? |
|
Definition
|
|
Term
| which atypical psychotherapeutic is a DA partial agonist and has reduced suspectibility to metabolic sxs and little to no wt gain? |
|
Definition
|
|
Term
| which is the only atypical agent to outperform perphenazine in terms of patient discontinuation? |
|
Definition
|
|
Term
| which atypical drug is the only one that is more efficacious than all of the typical drugs? |
|
Definition
|
|
Term
| Which psychotherapeutics drugs are better at treating negative symptoms and have fewer SEs? |
|
Definition
|
|
Term
| some new agents are better at controlling ______, but some cause ________ and __________. |
|
Definition
|
|
Term
| what are some additional SEs of paliperidone? |
|
Definition
|
|
Term
| which atypical agent can cause orthostatic hypotension? |
|
Definition
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