Term
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Definition
| A drug that elicits the responses for which it is given. It is the most important property that a drug can have |
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Term
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Definition
| Subtype of parmacokinetics (movement of drugs) |
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Term
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Definition
| Enteral (via gastrointestinal tract) and Parenteral (outside the intestinal tract; usually referred to as "by injection"; common routes intravenou, subQ, IM) |
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Term
| Factors influencing distribution |
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Definition
| Blood flow to tissue; exiting the vascular system; the blood brain barrier; placenta drug transfer |
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Term
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Definition
| The time for the amount of drug in the body to decrease by 50% |
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Term
| Phenytoin (Dilantin) Mechanism of action |
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Definition
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Term
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Definition
| Nystagmus; gingival hyperplasia; skin rash; sedation; ataxia; diplopia; cognitive impairment |
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Term
| Nursing Implications for Phenytoin |
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Definition
| Teach about good oral care; instruct patient to notify physician immediately if rash appears |
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Term
| Target serum level for Phenytoin |
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Definition
| 10-20 mcg/mL (levels below 10 are too low to control seizures and above 20 can produce toxicity |
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Term
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Definition
| Molecules that activate receptors |
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Term
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Definition
| Cause response by preventing receptor activation; 2 types are competitive and noncompetitive |
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Term
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Definition
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Term
| Noncompetitive Antagonist |
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Definition
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Term
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Definition
| An agonist that has only moderate intrinsic activity |
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Term
| Cytocrome p450 system-what does it do? |
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Definition
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Term
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Definition
| An uncommon drug response from a genetic predisposition |
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Term
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Definition
| Disease produced by physician |
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Term
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Definition
| Drug induced birth defects |
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Term
| Medical treatment for anaphylactic shock |
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Definition
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Term
| Signs and symptoms of anaphylactic shock |
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Definition
| Hypotension; Bronchial constriction; edema of the glottis |
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Term
| Mechanism of Action of Atropine |
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Definition
| Muscarinic antagonist: Produces its effects through competitive blockade at muscarinic receptor |
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Term
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Definition
| Increases heart rate; decreases secretions; relaxes bronchi; decreases bladder tone; decreases GI tone and motility; dilates the pupil; CNS excitation |
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Term
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Definition
| Disorders of the eye; bradychardia; intestinal hypertoxicity and hypermotility; muscarinic poisoning; asthmal; biliary colic; PUD |
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Term
| Adverse Effects of Atropine |
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Definition
| Dry mouth (xerostomia); blurred vision; photophobia; increased intraocular pressure; urinary retention; constipation; tachycardia; anhydrosis; asthma |
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Term
| How does renal excretion differ in children |
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Definition
| renal function is not achieved until one year of age so don't give meds that require renal excretion until age one |
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Term
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Definition
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Term
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Definition
| A neurodegenerative disorder of the extrapyramidal system associated with disruption of neurotransmissions within the striatum |
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Term
| What does the person with Parkinson's Disease look like? |
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Definition
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Term
| Side Effects of Parkinson's Disease |
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Definition
| Dyskinesias: Tremor at rest; rigidity; postural instability; bradykinesia |
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Term
| Therapeutic goal for Parkinson's Disease |
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Definition
| Improve activities of daily living (ADL) |
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Term
| Mechanism of Action for dopaminergic agents (used for parkinson's disease) |
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Definition
| Promotion of dopamine synthesis; prevention of dopamine degradation; promotion of dopamine release; direct activation of dopamine receptors |
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Term
Mechanism of Action for anticholinergic agents (used for parkinson's disease)
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Definition
| Blockade of muscarinic cholinergic receptors in the striatum |
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Term
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Definition
| ultrashort-acting drug, is the only depolarizing neuromuscular blocker in clinical use |
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Term
| What is succinycholine used for |
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Definition
| Muscle relaxation during endotracheal intubation, electroconvulsive therapy; endoscopy, and other short procedures |
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Term
| Succinycholine side effects |
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Definition
| Malignant hyperthermia; postoperative muscle pain; hyperkalemia; prolonged apnea in patients with low pseudocholinesterase activity |
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Term
| Treatment of benzodiazepine overdose |
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Definition
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Term
| Most common local anesthetics |
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Definition
| Procaine (used with epinephrine); lidocaine; cocaine (DO NOT USE WITH EPINEPHRINE) |
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Term
| Why would we use epinephrine with some local anesthetics |
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Definition
| Epinephrine is a vasconstrictor |
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Term
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Definition
| Can stabilize mood in patients with bipolar disorder |
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Term
| Normal Levels for lithium |
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Definition
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Term
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Definition
| 2nd or 3rd choice drugs: cause irreversible inhibition in MAO-A |
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Term
| Treatment for opioid overdose |
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Definition
| Ventilatory support; opioid antagonist (Narcan) |
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Term
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Definition
| Depression; Bulimia nervosa; OCD; reduction of panic attacks |
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Term
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Definition
| Avoid tyramine-rich foods (wine and cheese) |
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Term
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Definition
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Term
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Definition
| *Hypokalemia; hypotension; hyponatremia; ototoxicity; hyperglycemia; hyperuricemia; hyperlipidemia; dehydration; hypochloremia |
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Term
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Definition
| First-dose hypotension; *cough; hyperkalemia; renal failure; fetal injury; angioedema |
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Term
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Definition
| hypertension; heart failure; acute MI; left ventricular dysfunction; diabetic and nondiabetic nephropathy; prevent MI, stroke, death in patients at high risk for CV events |
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Term
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Definition
| Potent and efficacious vasodilator-the fastest acting antihypertensive agent available-drug of choice for hypertensive emergencies |
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Term
| How do administer nitropress |
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Definition
| Administer IV and hand in dark bag |
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Term
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Definition
| initial rate is .3 mcg/kg/min and max rate is 10 mcg/kg/min |
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Term
| Normal therapeutic level of digoxin |
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Definition
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Term
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Definition
| cardiotoxiciy: dysrhythmias are the most serious adverse effect of digoxin |
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Term
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Definition
| CNS effects; drowsiness; confusion; paresthesias |
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Term
| Once we experience problems with lidocaine what drugs would we give to correct those problems |
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Definition
| Equipment for resuscitation should be available as well as convulsions can be managed with diazepam or phenytoin |
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Term
| Normal starting dose for lidocaine |
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Definition
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