Term
| Qualities of a perfect drug |
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Definition
| Effectiveness, safety, selectivity |
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Term
| non-proprietary name of drug, assigned by US names council |
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Definition
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Term
| description of drug using nomenclature of chemistry |
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Definition
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Term
| drug movement through the body |
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Definition
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Term
| movement from site of entry to bloodstream |
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Definition
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Term
| movement of drugs throughout the body |
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Definition
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Term
| the method by which drugs are inactivated or biotransformed by the body |
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Definition
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Term
| the study of the influence of genes on individual response to drugs |
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Definition
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Term
| rate of metabolism is decreased in what kind of patients |
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Definition
infants (immature hepatic enzyme)
pt c liver or cardiac disease
pt on low-protein diets |
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Term
| time required for the serum concentration of a drug to decrease by 50% |
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Definition
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Term
| what drugs do to the body et how they do it |
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Definition
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Term
| largest effect that a drug can produce |
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Definition
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Term
| amount of drug we must give to elicit effect |
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Definition
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Term
| Morphine mechanism of action, metabolism, excretion, side effects |
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Definition
inhibits the release of substance P
metabolized by liver
excreted by kidneys
respiratory depression, N/V, hypotension, sedation, constipation, urinary retention, Increased ICP |
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Term
| First choice for severe pain, why |
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Definition
| Morphine- no ceiling, half-life 15-30hrs |
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Term
| antidote for opioid drugs |
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Definition
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Term
| Mechanism of action for Narcotic antagonists |
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Definition
| competes with opioids for receptor site, displaces opioids already occupying site. May cause withdrawl symptoms in opiate dependent ppl |
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Term
| Prototype of analgesic-antipyretic, anti-inflammatory drug |
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Definition
| Aspirin (acetylsalicytic acid) |
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Term
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Definition
| inactivation of cox-1 and cox-2; inhibits formation of prostaglandins. IRREVERSIBLY inhibits platelet Cox-1 |
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Term
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Definition
| Salicylism: tinnitus (ringing of ears), HA, dizziness, sweating. Reye's syndrome (fatal in children) |
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Term
| Prototype of NSAIDS, mech of action |
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Definition
| Ibuprofen: reversible inihibition of cox-1 and cox-2; anti-inflammatory, analgesic, and antipyretic properties. Antiplatelet only exist when drug is present in blood. |
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Term
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Definition
| mild-moderate pain/inflammation of musculoskeletal disorders, OA, RA, bursitis, gout |
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Term
| mechanism of action acetaminophen |
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Definition
| inhibition of synthesis in CNS only, no anti-inflammatory action. Metabolized by liver: do not mix with alcohol. |
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Term
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Definition
| acetylcysteine (mucomyst) |
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Term
| Adrenergic prototype, mech of action |
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Definition
| epinephrine, stimulates adrenergic receptors on cell membranes |
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