Term
| HMWK - High Molecular Weight Kininogen is what? Co-activates what? |
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Definition
| Is a bradykinin precursor and co-activates Factor XII |
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Definition
| In the presence of appropriate anionic surface and HMWK activates XII, generates bradykinin, activates plasminogen to plasmin, and pro-UPA to UPA. |
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Definition
| Adhesive platelet ligand that tethers platelet to exposed collagen at the sites of vascular injury (Primary hemostasis). Also a carrier protein for factor VII (secondary hemostasis). |
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Term
| Used to assess the activity of K-dependent clotting factors (II,VII,IX,X). Shows the extent of Vitamin K depletion from Warfarin Therapy. |
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Definition
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Definition
Class: anticoagulant
MOA: Vitamin K epoxide reductase inhibitors (2)
Mechanism of action: inhibition of the redox cycling of vitamin K (by VKOR), which leads to decreased production of prothrombin & other clotting factors
Chemical class: coumarin
Second most common drug related ER visits
Assay Patients CYP2C9 and VKORC1 genotype |
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Definition
UFH
Anticoagulant
CC: Polysaccharide
Negative sulfate group required for binding to antithrombin |
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Definition
LMWH
Smaller size translates to better selectivity for Xa and more favorable PK and PD properties |
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Definition
Argatroban
Therapeutic class (TC): anticoagulants
Pharmacological class (PC/MOA): direct inhibition of thrombin
Chemical class: most are peptides/proteins
Agent: Argatroban (Novastan®): small molecule (non-oral) peptidomimetic that reversibly inhibits thrombin
NONORAL |
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Definition
Aspirin
Therapeutic class (TC): anticoagulant
Pharmacological class (PC/MOA): COX-1 inhibitor
Chemical class: varies
Antiplatelet agents: Aspirin (acetylsalicylic acid, ASA) |
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Definition
Eptifibatide
Therapeutic class (TC): anticoagulant
Pharmacological class (PC/MOA): GPIIa/IIIB antagonist
Chemical class: peptidomimetic
Agent: Eptifibatide (Integrilin®) |
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Definition
Clopidogrel
Therapeutic class: anticoagulants
Pharmacological class (PC/MOA): P2Y12 (purinergic) receptor antagonists
Chemical class: thienopyridines
Agent: Clopidogrel bisulfate (Plavix®)
Major DDIx problems with CYP2C19 Substrates/inhibitors
EX: PPI |
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Definition
Dipyramidole
Therapeutic class (TC): anticoagulant
Pharmacological class (PC/MOA): inhibition of PDE-3 isozyme
Chemical class: varies
Agent: Dipyridamole (Persantine®, part of Aggrenox®) |
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Definition
Cholestyramine
Bile acid Resin/ Sequesterant
CC:Anion-Exchange resins
Coselevam may be preferred |
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Definition
Simvastatin
HMG-CoA Reductase
CC: 7 substituted 3,5 dihydroxyhepatanoic acid
Prodrug - very lipophilic and may have CNS effects
Hydroxyl very important |
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Definition
Atorvastatin
HMG-CoA Reductase Inhibitor
7 substituted 3,5 hepatanoic acid
Hydroxyl very important |
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Definition
Niacin
Niacin Receptor Agonist (NICR1,DGAT-2I)
CC: Nicotinic Acid
SAR: Carboxylic Acid |
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Definition
Fenofibrate
PPAR- alpha agonist
CC: Phenoxyisobutyric acid
Isobutyric acid - activity
P-chloro - longer half life |
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Definition
Gemfibrozil
PPAR-alpha agonist
CC: Phenoxyisobutyric acid
P-cholor derivative have much longer half life |
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