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Pharmacology Exam 2
Chapter 40: Cardiac Glycosides, Antianginals, Antidysrhythmics
12
Medical
Professional
03/05/2007

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Cards

Term
Lasix
Definition
High Ceiling Diuretic

-give potassium supplement


SE - Transient Deafness, Photosensitivity
Term
Nitroglycerin
Definition
Antianginal

-Strong Vasodialator
-Sublingual, High 1st pass affect
-Short t1/2 1-4 min
-Decreases the effect of Heparin
-Nitro Bid (paste) wear gloves

SE - Headaches
Term
Digoxin
Definition
Cardiac Glycoside (antidote: Digibind)

Must know 2 things:
apical pulse (never give if less than 60)
Potassium Levels - hypokalemia can lead to toxicity


Long t1/2: ~36hrs

SE - Vomiting = Increased loss of Potassium
Visual Disturbances such as halo's
Term
Cardiac Glycosides
Definition
A group of drugs that inhibit the sodium-potassium pump, increasing intracellular calcium, which causes the cardiac muscles to contract more efficiently.
Term
Name the 3 types of digitalis effects on the heart.
Definition
Inotropic, Chronotropic, Dromotropic
Term
What is the effect of a positive inotropic action?
Definition
Increases myocardial contraction stroke volume
Term
What is the effect of a negative chronotropic action?
Definition
Decreases heart rate
Term
What is the effect of a negative dromotropic action?
Definition
Decreases conduction of the heart cells.
Term
Name and define the 3 types of Angina Pectoris.
Definition
Classic/Stable: Occurs with stress or exertion

Unstable/Preinfarction: Occurs frequently over the course of a day with progressive severity.

Variant/Prinzmental, vasopastic: occurs during rest

first two caused by narrowing of coronary arteries.

Last by vasospasum
Term
Name all of the antianginal drug types.
Definition
Nitrates

Beta-adrenergic Blockers

Calcium Channel Blockers

Term
Normal Digoxin Levels are what?
Definition
.5 to 2 ng/ml
Term
ACC/AHA Stages of Heart Failure
Definition
1 High Risk for HF, without symptoms or structural disease.

2 Structural heart disease without symptoms of HF.

3 Structural heart disease with symptoms

4 Severe structural heart disease and marked symptoms of HF
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