Term
|
Definition
| against new tissue formation |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
antimetabolites
alkylating agents
plant alkaloids\
antibiotic antineoplastics
steroid hormones
antiestrogen
antiandrogen
biological response modifiers |
|
|
Term
|
Definition
leukemia, osteogenic sarcoma, squamous cell carcinoma, breast cancer, genital area malignancies
methotrexate, fluorouracil
cell cycle specific
S phase
vitamen supplements needed, folic acid |
|
|
Term
| antimetabolite side effects |
|
Definition
Anorexia, N, V, diarrhea
bleeding of oral mucosa
bone marrow suppression
leukopenia with infection
rash, itching, photosensitivity, scaling |
|
|
Term
| antimetabolite side effects |
|
Definition
Anorexia, N, V, diarrhea
bleeding of oral mucosa
bone marrow suppression
leukopenia with infection
rash, itching, photosensitivity, scaling |
|
|
Term
|
Definition
reduced form of folic acid
rescue agent to reduce methotrexate induced hematological and GI toxicity |
|
|
Term
|
Definition
used for brain tumors, sarcomas, lymphomas, leukemias
carmustine, cisplatin
affect replication of DNA |
|
|
Term
|
Definition
severe nausea and vomiting 1-2 hours after
use antiemtic, load fluids |
|
|
Term
| ankylating agent side effects |
|
Definition
severe nausea and vomiting, diarrhea
pulmonary fibrosis
hemorrhagic cystitis with heavy metal aldylating agents |
|
|
Term
|
Definition
| chemoprotectant, given prior to ifosfamide to prevent hemorrhagic cystitis from heavy metal alkylating ifosfamide |
|
|
Term
|
Definition
inhibit mitosis, cell division
used with other chemotherapeutic agents
vinblastine, vincristine
leukemias, Hodgkins disease, lymphomas, sarcomas
very toxic, once per week, largest dose 2mg |
|
|
Term
|
Definition
neurotoxicity
severe constipation, diarrhea, NV
oral or GI ulceration
rash, phototoxicity, alopecia |
|
|
Term
|
Definition
plant alkaloid, Western Yew
second line, subsequent therapy
metastatic breast or ovarian cancer refractory to conventional chemo |
|
|
Term
| paclitaxel/Taxol side effects |
|
Definition
bone marrow suppression, neutropenia, leukopenia, thrombocytopenia, anemia
hypersensitivity reac
peripheral neuropathy
NVdiarrea, mucositis
benedryl given before IV |
|
|
Term
|
Definition
exogenous antibodies
produce clone of single antibody |
|
|
Term
|
Definition
| relapsed or refractory non-Hodgkins lymphoma |
|
|
Term
|
Definition
combined with paclitaxcel
first line treatment of metastatic breast cancer |
|
|
Term
|
Definition
fever, chills, headache, dizziness
NV
Severe reactions: angioedema, hypotension, dyspnea, brochospasm, hypersensitivity, cardiac arrhythmias, angina, cardiomyopathy, \
hematological toxicitry
GI perforation
have antidotes ready |
|
|
Term
|
Definition
radioactive material injected (radiogold)
seeds
targeted therapy, MAB's with radioisotopes attached |
|
|
Term
|
Definition
ondansetron/Zofran
dolasetron/Anzemet, gramnisetron/Kytril |
|
|
Term
|
Definition
fluorouracil/Adrucil
methotrexate/Rheumatrex |
|
|
Term
|
Definition
carmustine, BCNE/BiCNU, Gliadel
cisplatin/Platinol
thiotepa/Thioplex |
|
|
Term
|
Definition
vinblastine/Velban
vincristine/Oncovin
paclitaxel/Taxol |
|
|
Term
| antibiotic antineoplastics |
|
Definition
bleomycin, can cause pulmonary fibrosis
doxorubicin, red devil, red urine
mitomycin, purple bands fingernails
treat leukemias, sarcomas, Hodgkins, lymphomas, brease cancerl, tumors: head, neck, testicles |
|
|
Term
| antibiotic antineoplastic side effects |
|
Definition
effect: lungs, kidneys, circulation
anorexia, nausea, vomiting, diarrhea
bone marrow suppression
cardiotoxicty (doxorubicin)
pneumonitis, dyspnea, rales, pulmonary fibrosis
ulceration mouth and colon |
|
|
Term
| antibiotic antineoplastic contraindications |
|
Definition
pregnancy
liver disorders
cardiac disease |
|
|
Term
|
Definition
corticosteroids
antiestrogen
antiandrogen |
|
|
Term
|
Definition
prednisone
dexamethasone/Decadron
prevention and treatment of NV before or with chemo |
|
|
Term
| corticosteroid side effects |
|
Definition
fluid retention
moon face
fatigue and weakness
osteoporosis |
|
|
Term
|
Definition
tamoxifen, nonsteroidal
metastatic estrogen receptor-positive breast cancer
alternative: anastrozole/Arimidex inhibits final step in estrogen production |
|
|
Term
|
Definition
leuprolide acetate/Lupron Dept
gonadatrophin releasing hormone, IM monthly for prosate cancer
oral: bicalutamide/Casodex |
|
|
Term
|
Definition
impotence
hot flashes, generalized pain, infection, constipation, nausea |
|
|
Term
| biological response modifiers |
|
Definition
interferons
leukemias, sarcomas, MS |
|
|
Term
| biological response modifier, Interferon side effects |
|
Definition
flulike symptoms
GI symptoms
nervous system effects |
|
|
Term
|
Definition
dexamethasone/Decadron
prednisone/Deltasone |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| biological response modifiers |
|
Definition
rituximab/Rituxan
trastuzumab/Herceptin |
|
|
