Term
| Describe the action of anti-inflammatory agents. |
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Definition
| Agents that block a step in the pathway leading from tissue injury to body response of inflammation |
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Term
| What are the classes of anti-inflammatory drugs? |
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Definition
| Salicylates and Non-sterioidal anti-inflammatory (NSAID) |
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Term
| Describe the link between salicylates and Reye's syndrome. |
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Definition
| unknown cause but deterioration of body occurs, increases liver enzymes, increased ammonia, fatty degeneration of liver, cerebral edema, leads to death; also why children w/chicken pox can't have it (liver enzymes) |
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Term
| List the signs and symptoms of salicylate toxicity. |
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Definition
| increased respiratory rate & depth, hemorrhage, convulsion, collapse, pulmonary edema |
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Term
| Describe aspirin dosage for 80+ yrs. old. |
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Definition
| 81/mg a day for women: reduces risk of stroke, men: reduce risk of heart attack |
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Term
| Describe what an enteric coated aspirin does? |
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Definition
| Coated so it goes straight to small intestine |
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Term
| What is different about the new NSAIDs? |
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Definition
| the selectively inhibit COX 2 (celeoxib) so less inflammation at injury site and fewer side effects |
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Term
| What are the prototypes for NSAIDs? |
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Definition
| Ibuprofen and acetminophen |
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Term
| Discuss the use and misuse of acetaminophen. |
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Definition
| More than 40% of liver problems in US are due to tylenol over use. 70% of tylenol overdose thought to be intention, 30% accidental; elderly at more risk. |
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Term
| Describe the adverse effects of acetaminophen |
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Definition
| acute liver failure, often used for suicide, if w/cumidin, will increasing bleeding time; |
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Term
| Interferons: what are they? what is the MOA? |
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Definition
| chemicals that are produced by cells that have been invaded by viruses, made by recombinant technology; MOA: prevent viral replication inside other cells, stimulating receptor sites on non-invaded cells to produce anti-viral proteins which helps to block entry into cells, lessen tumor growth and replication |
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Term
| Interleukins: What are they? What is the MOA? |
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Definition
| chemical messengers secreted by T cells to affect other leukocytes; specifically interleukin 2 which stimulates production of more T cells and increases activity of B cells, cytotoxic cells and natural killer cells; MOA: mimics action of natural IL 2 |
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