Term
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Definition
| T4 thyroid hormone replacement |
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Term
|
Definition
| T3 thyroid hormone replacement |
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Term
|
Definition
| Common drugs that increase synthetic thyroid hormone metabolism |
|
|
Term
| Levothroxine, Liothyronine |
|
Definition
| Tx of hypothyroidism, myxedema coma |
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Term
|
Definition
| Preferred TH in myxedema coma due to faster onset of action |
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Term
|
Definition
| Preferred tx for hypothyroidism due to longer half life |
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|
Term
Iodine uptake inhibitors
(Perchlorate, Thiocyanate, Pertechnetate) |
|
Definition
tx of hyperparathyroidism via competition with iodide for uptake into thyroid gland follicular cells via Na-I symporter
decreases intrathyroidal supply of iodide available for thyroid hormone synthesis
also used as radiocontrast agent
rarely used to due risk of aplastic anemia |
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|
Term
131I- (radioactive iodide) |
|
Definition
Mediates selective local destruction of the thyroid gland via emission of toxic β particles
may cause hypothyroidism or worsen opthalmopathy |
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|
Term
| Iodide (high concentrations) |
|
Definition
tx of hyperthyroidism
inhibits iodide uptake and organification via Wolff-Chaikoff effect; downregulates Na-I symporter
may worsen goiters
only temporary suppression
useful before surgery to reduce vascularity and size of thyroid gland |
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Term
|
Definition
thioamine used in tx of hyperthyroidism
inhibits thyroid peroxidase and inhibits peripheral conversion of T4 to T3
short half life
preferred tx during thyroid storm and pregnancy |
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Term
|
Definition
thioamine used in tx of hyperthyroidism
only inhibits thyroid peroxidase
generally preferred clinically due to reduced side effects
administerd once daily |
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Term
|
Definition
preferred β blocker used in tx of thyroid storm due to rapid onset and short half-life
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|
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Term
|
Definition
used to tx symptoms of hyperthyroidism
blocks 5'-deiodinase, inhibiting peripheral conversion of T4 to T3 |
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|
Term
|
Definition
former radiocontrast agent
no longer available |
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|
