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Pharmacology Blood/Hematology
Blood/Hematology
12
Architecture
Undergraduate 1
05/09/2012

Additional Architecture Flashcards

 


 

Cards

Term
Treatment for Lead Toxicity for adults and children
Definition
Adults:
EDTA
Succimer

Children:
EDTA
Dimercaprol
Succimer
Term
Lead toxicity inhibits these enzymes
Definition
aminolevulinic acid dehydrogenase
Ferrochetolase
Term
Platelet inhibitors
Definition
Copidogrel (plavix)
Ticlopidine
--blocks the ADP receptor on platelets so that GpIIb/IIIa cannot be expressed
Consider using this in patients who cannot use Warfarin.

Asprin
--Prevents creation of TXA2

Abxicimab
--Antibody against GpIIb/IIIa
Term
Drug treatment for Von Willebrand's Disease
Definition
DDVAP - analog of vasopressin

"squeezing" the good vWF out of the endothelial cell
Term
Drug used for Acute anti Coagulation
Definition
Heparin

MOA: stimulates Antithrombin III to decrease thrombin and factor Xa. Monitor via intrinsic pathway PTT.

Does not cross placenta. Safe for pregnant women.
Term
Drug used for chronic anti coagulation
Definition
Warfarin

MOA: inhibits epoxide reductase. Decreases the Vitamin K dependent clotting factors (II,VII,IX,X,C,S). Monitor via PT levels

May produce a transient hypercoagulable state (acts on protein C/S first). Coadminister with Heparin

Teratogenic, crosses placenta to cause hydrops
Term
Drug used for its thrombolytic activity
Definition
tPA (alteplase)
streptokinase
urokinase

MOA: converts plasinogen to plasmin

Used for ischemic strokes, Myocardial infarction therapies.
Term
Treatment for Heparin Toxicity
Definition
Protamine sulfate

positively charge molecules bind to negatively charged Heparin molecules.
Term
Treatment for Warfarin toxicity
Definition
Vitamin K (to restore clotting factors)
Fresh Frozen Plasma (to immediately address hemorrhage)
Term
Treatment for thrombolytic toxicity
Definition
Aminocaproic acid

Inhibitor of fibrinolysis
Term
Drug used for Heparin Induced Thrombocytopenia
Definition
Lepuridin
Bivalirudin

Directly decreases thrombin
Term
Drug treatment for Sickle Cell patients
Definition
Hydroxyurea (in addition with fluid therapy)
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