Term
|
Definition
Trospium
Oxybutynin
Tolterodine
Solifenacin
Darifenacin
"TOTS" |
|
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Term
|
Definition
Acetyl Coa + Choline --> ACh (choline acetyl transferase)
ACh enters vesicle
Ca helps vesicle degranulate
4 fates:
ACh receptor
ACh degredation
ACh reuptake with autoreceptor
Diffuse away |
|
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Term
|
Definition
| Inhibits ACh entering the vesicle |
|
|
Term
|
Definition
| Inhibits entry of choline into the neuron. Doesn't form with Acetyl CoA |
|
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Term
|
Definition
Phe --> Tyrosine (Phe Hydroxylase)
Tyrosine --> DOPA (Tyr Hydroxylase)
DOPA --> Dopamine (DOPA Decarboxylase)
Dopamine --> NE (Dopamine B Hydroxylase)
NE --> Epi (PNMT)
NE released from vesicle via Ca
4 Fates:
alpha1, alpha2, beta1, beta2 Receptors
Reuptake via autoreceptor
Metabolism via MAO/COMT |
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Term
|
Definition
| Inhibits tyrosine hydroxylase in formation of NE |
|
|
Term
| Inhibits NE Autoreceptors on noradrenergic nerves |
|
Definition
|
|
Term
| Stimulates release of NE in noradrenergic pathway |
|
Definition
Amphatamines
Ephedrine
Tyramine |
|
|
Term
| Blocks NE from exiting noradrenergic nerve |
|
Definition
|
|
Term
| Effect of Alpha 2, Muscarinic M2, and Angiotensin II on Noradrenergic NE release |
|
Definition
Decreased
Decreased
Increased (vasoconstriction) |
|
|
Term
| Inhibits Dopamine to enter Vesicle to convert to NE |
|
Definition
|
|
Term
|
Definition
7 membrane subunit
Gs protein subunits
Activates Adenylyl Cyclase
Creates cAMP from ATP
Stimulates Protein Kinase A |
|
|
Term
|
Definition
7 transmembrane receptor
Gq Protein subunit
Activates Phospholipase C
Cleaves PIP3 (from membrane) into:
DiacylGlycerol (DAG) to make Protein Kinase C
IP3 to stimulate Ca release from SR |
|
|
Term
| Tyrosine Kinase Receptor pathway |
|
Definition
Insulin binds to 2 transmembrane receptor
Autophosphorylation of its own Tyr
Eventual activation of p21Ras
Ras signal molecule to effect growth |
|
|
Term
| Gs proteins stimulated by what receptors |
|
Definition
|
|
Term
| Gq proteins stimulated by what receptors |
|
Definition
H1
A1
V1
M1
M3
"GQ's have 1 M&M" |
|
|
Term
| Gi proteins stimulated by what receptors |
|
Definition
|
|
Term
| Sympathomimetics (direct) |
|
Definition
Epinephrine a1,a2,b1,b2 (for anaphylaxis, asthma)
NE a1,a2>b1 (Hypotension)
Isoproterenol B1=B2 (AV block)
Dopamine D1=D2>B>a (Shock with inc renal)
Dobutamine B1>B2 (for heart failure, stress test, cardio shock)
Phenylephrine a1>a2 (pupil dil., nasal decongestion)
B2 Agonists
Metaproterenol
albuterol/levalbuterol
salmeterol
terbutaline |
|
|
Term
| Indirect Sympathomimetics |
|
Definition
Amphetamine - release stored (narcolepsy, obesity, ADD)
Ephedrine - release stored (nasal decongestion)
Cocaine - uptake inhibitor (vasoconstriction) |
|
|
Term
|
Definition
| Clonidine - centrally acting A2 agonist (for hypertension) |
|
|
Term
|
Definition
Nonselective
Phenoxybenzamine (pheochromocytoma)
Phentolamine
Alpha1 selective
Prazosin, terazosin, doxazosin (HTN and BPH - will get first dose orthostatic Hypotension)
Alpha 2 selective
Mirtazapine (depression) |
|
|
Term
|
Definition
Beta 1 selective
Acebutolol
Betaxolol
Esmolol
Atenolol
Metoprolol
"A BEAM"
Nonselective
Propranolol |
|
|
Term
|
Definition
|
|
Term
|
Definition
"Chol"
Bethanechol (post op ileus and urinary retention)
Carbachol (glaucoma)
Pilocarpine (glaucoma emergency, simulates sweat/tears)
Methacholine (Challenge test for asthma) |
|
|
Term
| Indirect Cholinergic agonists |
|
Definition
Anticholinesterases
Neostigmine (myasthenia gravis)
Pyridostigmine (myasthenia gravis)
Edrophonium (MG diagnostic test)
Physostigmine (glaucoma)
Echothiophate (glaucoma) |
|
|
Term
| Drug to regenerate active cholinesterase |
|
Definition
|
|
Term
|
Definition
"-trop"
Atropine (Tx for Organophosphate poison, ACLS drug, otometry drug)
Benztropine (Parkinsons Disease)
Scoplamine (motion sickness)
Ipratropium (asthma)
Oxybutynin (urinary urge)
Methscoploamine (PUD)
Propantheline (PUD |
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