Term
Binds to ergosterol, and forms membrane pores that allow leakage of electrolytes
Used for systemic mycoses |
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Definition
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Term
| Toxicity of Amphotericin B |
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Definition
Nephrotoxicity, arrythmias, IV phlebitis, fevers/chills
(causes membrane instability with loss of K and Mg) |
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Term
Binds to ergosterol, disrupting fungal membranes, too toxic for systemic use
Used locally only |
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Definition
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Term
Inhibits fungal sterol (ergosterol) synthesis
Toxicity: Causes hormone synthesis inhibition (gynomastia) and liver disfunction (inhibits P450) |
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Definition
Azoles:
Fluconazole
Ketoconazole
Clotrimazole
Miconazole
Itraconazole
Voriconazole |
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Term
Inhibits DNA synthesis by conversion to 5-fluorouracil
Used in systemic fungal infections in combination with Amphotericin B
Toxicity:...? |
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Definition
FlUcytosine
Bone marrow suppression! Acts like 5-FU |
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Term
Inhibits cell wall synthesis by inhibiting synthesis of B-glucan
Used for invasive aspergillosis |
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Definition
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Term
Inhibits the fungal enzymes: squalene epoxidase
Used for dermatophytoses (especially onychomycosis) |
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Definition
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Term
Interferes with microtubule function, disrupts mitosis.
Deposits in keratin containing tissue (nails).
Affects P450 |
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Definition
Griseofulvin
Induces P450! |
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