Term
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Definition
| Direct-Acting Muscarinic Agonist |
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Term
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Definition
Direct-Acting Muscarinic Agonist
-Glaucoma |
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Term
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Definition
Direct- Acting Muscarinic Agonist
-pulmonary function testing for asthma |
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Term
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Definition
Direct-Acting Muscarinic Agonist
-GI motility, Urinary Retention |
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Term
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Definition
Direct-Acting Muscarinic Agonist
-glaucoma, xerostomia |
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Term
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Definition
Direct-Acting Muscarinic Agonist
-salivary gland dysfunction |
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Term
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Definition
-Cholinesterase Inhibitor
-Tensilon Test, diagnose myasthenia gravis
-short acting |
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Term
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Definition
Cholinesterase Inhibitor
-treat atropine or anti-muscarinic poisoning |
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Term
| Neostigmine + Pyridostigmine |
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Definition
Cholinesterase Inhibitor
-myasthenia gravis, anti-nerve gas |
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Term
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Definition
Cholinesterase Inhibitor
-Alzheimer's |
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Term
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Definition
Cholinesterase Inhibitor
-glaucoma |
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Term
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Definition
Cholinesterase Inhibitor
-Alzheimer's |
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Term
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Definition
Cholinesterase Inhibitor
-Irreversible, Treat only with Atropine |
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Term
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Definition
Cholinesterase Inhibitors
-Irreversible, use atropine/pralidoxime |
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Term
| Organophosphate (Parathion, Malathion) |
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Definition
Cholinesterase Inhibitors
-irreversible,use atropine/pralidoxime |
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Term
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Definition
Cholinesterase Inhibitor
-irreversible nerve gas |
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Term
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Definition
Cholinesterase Reactivator
-only for organophosphates |
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Term
| Sildenafil, Vardenafil, Tadalafil |
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Definition
Cyclic GMP 5 Inhibitors
-ADR: hypotension, increased heart rate |
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Term
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Definition
| prevents release of Acetylcholine |
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Term
| Anticholinergic/Anti-muscarinic Drugs |
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Definition
competitive antagonist at muscarinic receptors
-poisoning treat with physostigmine |
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Term
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Definition
| Antimuscarinic -prototype -CNS: low dose sedative, high dose stimulate |
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Term
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Definition
Anti-muscarinic
-CNS depressant, treats vertigo/motion sickness |
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Term
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Definition
Anti-msucarinic
-intestinal anti-spasmodic |
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Term
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Definition
Anti-muscarinic
-intestinal anti-spamodic |
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Term
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Definition
Anti-muscarinic
-no CNS effect, dry respiratory secretions
-inhibit vagal reflexes |
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Term
| Ipratropium and Tiatropium |
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Definition
Anti-muscarinics
-asthma and COPD |
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Term
| Benztropine and Trihexyphenidyl |
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Definition
Anti-muscarinic
-Parkinson's |
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Term
| Tolterodine, Oxybutynin, and Solifenacin |
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Definition
Anti-muscarinic
-Urinary incontinence |
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Term
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Definition
Anti-muscarinic
-dilates pupils |
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Term
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Definition
| work on junction to cause relaxation of paralysis of skeletal muscle |
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Term
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Definition
Neuromuscular Blocker
-non-depolarizing blocker |
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Term
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Definition
Neuromuscular Blocker
-depolarizing, cannot be overcome by cholinesterase inhibitors |
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Term
| Peripherally-Acting Adrenergic Neuronal Inhibitors |
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Definition
| decrease availability of NE to receptors |
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Term
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Definition
Peripherally-acting Adreneric Neuronal Inhibitor
-decreases uptake of DA and NE
-treat hypertension
-irreversible, long-acting |
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Term
| Centrally-Acting Adrenergic Neuronal Inhibitors |
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Definition
| Stimulate A2 sites in the brain and reduce sympathetic traffic |
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Term
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Definition
Centrally-Acting Adrenergic Neuronal Inhibitor
-prodrug
-treat hypertension in pregnancy |
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Term
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Definition
Centrally-Acting Adrenergic Neuronal Inhibitor
-small, absorbed thru skin
-must be tapered or rebound hypertension
-migraine, ADHD, PTSD, drug withdrawal |
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Term
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Definition
Centrally-Acting Adrenergic Neuronal Inhibitor
-lowers cholesterol, less sedation
-treats ADHD |
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Term
| Ganglionic Stimulants and Blockers |
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Definition
Act on neuronal NICOTINIC receptors
Low dose stimulant, high dose depressant |
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Term
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Definition
Ganglionic Nicotinic Stimulant/Blocker
-low dose stimulant, high dose depressant
-adrenergic agonists can help treat high dose blockade |
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Term
| Direct Acting Sypathomimetics (Adrenergic Receptor Agonists) |
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Definition
Alphas Constrict, Betas Dilate
-tolerance, rebound common |
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Term
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Definition
Non-selective Adrenergic Agonist
-stimulates A and B receptors |
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Term
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Definition
Non-selective Adrenergic Agonist
-stimulates A and B1, not B2
-reflex bradycardia
-Neurogenic shock: stimulates both heart and blood vessels
-Sepsis: early "warm" phase can reverse vasodilation |
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Term
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Definition
Non-selective Adrenergic Agonist
-stimulates betas, not used in asthma anymore
-diagnoses unexplained syncopes |
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Term
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Definition
Non-selective Adrenergic Agonist
-low dose (dopamine receptors), medium dose (beta1), high (Alpha1)
-Neurogenic shock (stimulates both heart and blood vessels)
-Sepsis: "warm"=vasoconstrictor (A1), "cold"=reverse low CO (B1 stimulated) |
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Term
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Definition
Selective B1 Agonist
-increases cardiac contractility, stimulates heart during surgery
Cardiac Shock: stimulates Beta1
Sepsis: "cold"=reverse low CO |
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Term
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Definition
Selective B2 agonist
-Treat bronchoconstriction in asthma and COPD, exercise induced bronchospasms |
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Term
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Definition
Selective B2 agonist
-Treat bronchoconstriction in asthma and COPD, exercise induced bronchospasms |
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Term
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Definition
Selective B2 agonist
-Treat bronchoconstriction in asthma and COPD, exercise induced bronchospasms |
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Term
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Definition
Selective B2 agonist
-Treat bronchoconstriction in asthma and COPD, exercise induced bronchospasms
-longest acting |
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Term
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Definition
Selective B2 agonist
-prevent premature labor by causing uterine relaxation |
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Term
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Definition
Selective A1 agonist
-more reflex bradycardia, increased BP
-maintains diastolic and mean BP in neurogenic shock (blood vessels only)
-nasal decongestant, mydriatic agent, hemorrhoids |
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Term
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Definition
Selective A1 agonist
-orthostatic hypotension |
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Term
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Definition
Indirect Acting Sympathomimetic
-inhibits reuptake of NE (constricts BV at local site)
-not effective orally |
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Term
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Definition
Indirect-Acting Sympathomimetic
-stimulates release of NE independent of action potentials
-treats nasal congestion and promotes sinus drainage |
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Term
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Definition
cleared by liver
-may aggravate Raynaud's or cause exercise intolerance
-may have severe hypoglycemic reaction to insulin
-sudden withdrawal causes rebound hypertension and angina |
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Term
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Definition
decrease HR and contractility, treat hypertension
-decrease conduction velocity of AV node
-prevent "thyroid storm" in hyperthyroidism |
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Term
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Definition
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Term
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Definition
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Term
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Definition
Selective B1 Blocker
-metabolized by ESTERASES
-short duration |
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Term
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Definition
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Term
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Definition
Non-selective B1 and B2 blocker
-long acting |
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Term
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Definition
Non-Selective B1 and B2 Blocker
-partial agonist |
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Term
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Definition
| Non-selective B1 and B2 Blocker |
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Term
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Definition
| Non-selective B1 and B2 Blocker |
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Term
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Definition
Non-selective B and Selective A1 Blocker
-treats SEVERE hypertension |
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Term
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Definition
Inhibitions of peripheral A-receptors
-ADR: too much loss of A-receptors (congestion, reflex tachycardia, fluid retention, hypotension) |
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Term
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Definition
Non-selective A-Blocker
-noncompetitive, irreversible (long-acting)
-prevent hypertension in pheochromocytoma PRIOR to surgery
-toxic, bad ADRs |
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Term
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Definition
Non-selective Alpha Blocker
-diagnose pheochromocytoma, short acting, given DURING surgery
-treat vasoconstriction, prevent dermal tissue necrosis
-reverse oral soft tissue anesthesia |
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Term
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Definition
Selective A1 Blocker
-mild to moderate hypertension with diuretic
-treat BPH, Raynaud's, nightmares with PTSD
-ADR: first dose phenomenon of hypotension |
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Term
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Definition
Selective A1 Blocker
-long half-life, not for PTSD |
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Term
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Definition
Selective A1 Blocker
-subgroup A1A found on bladder, less systenic ADRs
-treat BPH |
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Term
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Definition
Selective A1 Blocker
-treat BPH, not sub-type selective
-"uroselectivity" accumulates in prostatic tissue |
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Term
| Parkinson's and Other movement disorders |
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Definition
-blocking dopamine in the striatum of the brain by anti-psychotics can cause Parkinson's (reserpine and metoclopramide)
-Clozapine: treatment of psychotic effects of Dopa Drugs |
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Term
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Definition
Dopaminergic Agent
-dopamine precursor, not given alone
-does not halt progression,
-"end of dose phenomenon"
-ADR:nausea, hypotension, tachycardia |
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Term
| L DOPA/ Carbidopa (Sinemet) |
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Definition
Dopaminergic Agent
-inhibits DOPA decarboxylase in periphery |
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Term
| L DOPA/Carbidopa/Entacapone |
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Definition
Dopaminergic Agent
-inhibits metabolism of dopamine by COMT |
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Term
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Definition
| Dopaminergic Agent -not as effective as DOPA -not approved to inhibit prolactin secretion anymore -used with L DOPA but with additive side-effects |
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Term
| Pramipexole and Ropinirole |
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Definition
Dopaminergic Agent
-D2 and D3 receptors
-may have antioxidant and neuroprotective effects which may slow progression |
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Term
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Definition
Dopaminergic Agent
-stimulate release of dopamine |
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Term
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Definition
MAO-B Inhibitor
-inhibit metabolism of dopamine by MAO-B in CNS
-studies do not confirm that it slows progression
-ADR: "cheese toxicity" |
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Term
| Benztropine and Trihexyphenidyl |
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Definition
COMT inhibitor
-more effective against tremors
-treatment of iatrogenic Parkinson's due from DA antagonists |
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Term
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Definition
Antihistamine
-due to anti-cholinergic effect |
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