Term
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Definition
| Highest abuse potential. Highest physical and psychological dependence Limited or not therapeutic use. EX. Heroin, LSD, Methaqualone |
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Term
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Definition
| High abuse potential High physical and psychological dependence Therapeutic use with prescription Some drugs no longer used. EX. Morphine, PCP, Cocaine, Methadone, Methamphetamine |
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Term
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Definition
| Moderate abuse potential Moderate physical dependence High psychological dependence Therapeutic use with prescription EX. Anabolic steroids, Codeine w aspirin or Tylenol, Some Barbituates |
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Term
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Definition
| Lower abuse potential Lower physical and psychological dependence Therapeutic with prescription. Ex. Dextropropxyphene, Pentazocine, Meprobamate, Diazepam, Alprazolam |
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Term
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Definition
| Lowest abuse potential, lowest physical & psychological dependence, Therapeutic use w/o prescription Ex. OTC cough medicines with codeine |
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Term
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Definition
| Adequate, well-controlled studies in pregnant women have not shown an increased risk of fetal abnormalities. |
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Term
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Definition
| Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate and well-controlled studies in pregnant women, or Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus. |
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Term
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Definition
| Animal studies have shown adverse effect and there are no adequate and well-controlled studies in pregnant women, or No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women. |
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Term
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Definition
| : Studies, adequate well-controlled or observational, in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy outweigh the potential risk. |
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Term
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Definition
| Studies, adequate well-controlled or observational, in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. The use of the product is contraindicated in women who are or may become pregnant. |
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Term
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Definition
| Movement of drug particles from the GI tract to body fluids. Small Intestine, First Pass Effect |
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Term
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Definition
| Process by which drugs are made available to body fluids and tissues. Effected by blood flow, tissue affinity (attraction) and protein binding (efficacy ability to work) |
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Term
| Metabolism (biotransformation) |
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Definition
| Primary liver, also GI tract. Liver disease can alter drug metabolism by inhibiting the drug-metabolizing enzymes. Accumulation may = toxicity |
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Term
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Definition
Kidney’s primarily (Free, Water soluble, Unchanged)
Also hepatic metabolism, bile, feces, lungs, saliva, sweat, & breast milk.
Protein- bound drugs cannot be filtered through the kidneys.
Kidney disease = slowed impaired drug elimination, which may = toxicity
Decreased renal blood flow can alter drug excretion |
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