1.Patient name, room number or address, and identification numbers 

2. Drug name (generic or brand)

3. Dosage (in proper units of measure for particular drug) 

4. Dosage form (e.g., tablet, injection, solution) 

5. Route of administration (e.g., oral, parenteral, rectal) 

6. Date order is written 

7. Prescriber’s signature

four components of pharmacokinetics 

absorption

distribution

metabolism

excretion

examples of agents that are attracted to adipose tissue 

thiopental ( pentothal )

diazepam ( valium ) 

lipid soluble vitamins.

received a lower body supply 

skin

bone

adipose tissue

receive the most blood supply

heart

liver 

kidney

brain

factors affecting distribution

cardiac output

regional blood flow

drug reservior

barriers to distribution

blood brain barrier

placental barrier

first pass effect sequence 

a) drugs are absorbed

b) drugs enter hepatic portal circulation and go directly to liver

c) hepatic microsomal enzymes metabolize drugs to inactive forms

d) drug conjugates, leaving liver

e) drug is distributed to general circulation 

pharmacokinetics values

minimum effective concentration

toxic concentration 

therapeutic range