Term
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Definition
1. passive diffusion: diffuses across membranes like gases and lipophiles
2. active transport: transport against concentration gradient with ATP (acid base excretion renal)
3. facilitated diffusion - only via concentration gradient (adenosine)
4. receptor mediated endocytosis: peptide hormones |
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Term
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Definition
mvmnt for water soluble drugs
-applies to fetus
-bbb stops water soluble drug entry (tight junctions) |
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Term
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Definition
acidification traps charged form weak bases!
alkalinization traps charged form weak acid |
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Term
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Definition
| MDR expressed everywhere (organic cation) |
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Term
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Definition
| Much of the drug is absorbed and metabolized within stomach/liver before entering systemic circ. |
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Term
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Definition
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Term
| drugs bound to serum proteins |
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Definition
1.albumin = warfarin
2. glycoprotein = lidocian
3. lipoproteins - propofol |
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Term
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Definition
| Volume distribution...larger means undergoes tissue binding |
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Term
| zero order vs first order |
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Definition
zero = constant rate (sat receptor)
1st = proportional to concentation
(most drugs) |
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Term
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Definition
phase 1 = oxidation by p450s
phase 2 = conjugation
t1/2 = .693/ke |
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Term
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Definition
additive, used as measure of loss of particular concentration of fluid
C=ke * vd |
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Term
| two compartment dist phase |
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Definition
I-injection co
II - entry tissues co
III - slow elimniztion
IV
distribution phase ends when periphral and circ enter equillibrium (III) |
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Term
| when to use large dosing fraction and why |
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Definition
less frequent dosing...large theraputic window only
smaller f keeps concentration in smaller window but needs admin more often |
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Term
| nonlinear dose dependant drugs |
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Definition
peak concentration changes non-proportionately to dose
occurs saturated kinetic process
may not reach steady state at higher doses |
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Term
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Definition
= drug plasma/drug alveolus
decreasing solubility = decreasing coefficient = equilibruim faster |
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