PHARMACOKINETICS
(What the body does to the drug.)

Absorption

Absorption (cont.)

Factors affecting absorption

Blood circulation

Pain, stress

Food texture, fat content, temperature

pH

Route of administration

Drug movement from the GI tract to the liver

Via portal vein

First, the pass effect

Bioavailability

First Pass Effect

Metabolism

Once a drug has been absorbed and distributed in the body, it will then be broken down by a process known as metabolism.

Excretion

The kidney often filters the remaining drugs and metabolites in the bloodstream. Where a portion undergoes reabsorption back into the bloodstream, and the remainder is excreted in the urine.

Pharmacodynamics
(What the drug does to the body.)

Affinity

Efficacy

Potency

Medication Types

Medication Effects

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Preparing for Administration

Selectivity

Side Effects

Adverse Effects

To make safe medication administration decisions, the nurse must have a strong understanding of?

A drug agonist competes to decrease a desired effect. A drug antagonist competes with other molecules and blocks a specific action or response at a receptor site.

 A drug agonist binds tightly to a receptor to produce the desired effect. A drug antagonist competes with other molecules and blocks a specific action or response at a receptor site.

 A drug antagonist binds tightly to a receptor to produce the desired effect. A drug agonist competes with other molecules and blocks a specific action or response at a receptor site.

 A drug agonist and antagonist depend on the receptor to which it binds.

True or False: Metabolism is not affected by the patient’s liver function.

TRUE

FALSE