Term
| whats the difference between pharmacokinetics and pharmacodynamics |
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Definition
pharmacokinetics is the body's effect on the drug
pharmacodynamics is the drugs effect on the body |
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Term
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Definition
| a carbon with 4 different substituents |
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Term
| the subtypes of a chiral carbon are |
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Definition
1. levorotatory enationmer
2. dextrorotatory enatiomer |
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Term
| rate of passive diffusion is determined by what two factors of drugs |
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Definition
1. lipid solubility
2. concentration gradient |
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Term
| primary mechanism of transport in placenta is by |
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Definition
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Term
| is fetal pH or maternal pH more acidic |
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Definition
| fetal circulation is more acidic |
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Term
| the two primary plasma proteins are |
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Definition
1. albumin #1
2. alpha 1 - acid glycoprotein |
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Term
| the greater the protein binding then the greater or lesser the lipid solubility?? |
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Definition
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Term
| Three populations of patients that have decrease plasma proteins |
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Definition
1. elderly
2. liver disease
3. renal disease |
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Term
| what type of kinetics is the removal of a constant fraction in a period of time |
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Definition
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Term
| what type of kinetics is the removal of a drug at a constant rate per unit of time |
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Definition
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Term
| drug elminiation is considered complete after how many half lifes |
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Definition
| 4-5 elimination half lives |
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Term
| Describe the tri-exponential decay curve |
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Definition
| Describes the distribution and elminiation phases of any drug in the boyd. Three phases, pi, alpha and beta. Pi and alpha represent the distribution phase. Pi is distribution immediately to the vessel rich groups, then alpha is distribution to non-vessel rich group. Beta is the elminitaion phase. |
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Term
| generally a lipophillic drug will have more or less VOD |
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Definition
| MORE! b/c lots go into lipid containing tissues and therefore larger vod. |
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