Term
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Definition
What drug does to body
D+R<-->DR |
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Term
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Definition
| Dose at which 50% of patients have therapeutic effect |
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Term
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Definition
| The dose at which 50% pts experience toxicity (side effects) |
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Term
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Definition
| Dose at which 50% pts would die |
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Term
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Definition
| Window between therapeutic effect and the toxic effect at which that effect is acceptable |
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Term
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Definition
TD50/ED50
higher index-wider and better window
lower index- smaller and worse window |
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Term
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Definition
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Term
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Definition
| Elicits maximal response and stabalizes DR* |
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Term
| Partial/Mixed agonists-antagonists |
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Definition
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Term
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Definition
Receptors that are active naturally are made inactive
stablizes DR in the case of R* |
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Term
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Definition
inhibits agonist activity
stabalization of DR, prevention of DR*
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Term
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Definition
| reversible binding, can be bumped |
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Term
| Noncompetitive Antagonist |
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Definition
| irreversible binding to active site or allosteric site, cant be bumped |
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Term
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Definition
chemical-agonists inactivation
physiologic-mediates oppopsite response of agonist |
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Term
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Definition
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