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Pharmacodynamics
Pharmacodynamics Test 1
9
Pharmacology
Undergraduate 4
01/31/2018

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Term
Affinity
Definition
ability to accumulate and store drugs after absorption; attraction between a drug and a receptor
Term
Agonist
Definition
drug that produces the same type of response as the endogenous substance [hormone or neurotransmitter]; the drug mimics the effect of the endogenous regulatory molecule
Term
Antagonist
Definition
drug will occupy a receptor and prevent the endogenous substance from acting on the receptor; also called a receptor blocker; often compete with agonist for receptor binding site, preventing agonist from binding to receptor
Term
Mechanism of Action
Definition
how a drug produces its effect in the body; it is also called the pharmacologic effect; usually refers to the drug action on a receptor, enzyme, or other macromolecule; does not refer to the effect the drug has on the body
Term
Nonspecific cellular responses
Definition
responses that occur independently of cellular receptors, and are associated with other mechanisms, such as changing the permeability of cellular membranes, depressing membrane excitability, or altering the activity of cellular pumps
Term
Partial-agonist
Definition
a drug that produces a weaker, or less efficacious, response than an agonist
Term
Receptor
Definition
a cellular protein macromolecule to which a medication binds in order to initiate its effects
Term
Selectivity
Definition
specificity of the binding means that drugs can be produced that are selective for specific types [and subtypes] of receptors; an interaction of a drug with a receptor elicits primarily one effect or response
Term
Specificity
Definition
an interaction of the drug with preferentially one receptor class or a single receptor subtype
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