Term
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Definition
| -design and manufacture of drug products |
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Term
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Definition
-physical form
-delivery route
-release profile |
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Term
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Definition
-API identity
-purity
-quantity
-uniformity
-stability
-ease of administration
-drug release
-manufacturability
-low cost |
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Term
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Definition
| -science of small particles |
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Term
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Definition
-dissolution
-suspendability
-uniformity distribution of active in a dry powder blend
-penetrability of particle intended to be inhaled
-non-grittiness of particles in dermal preparations |
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Term
| smallest visible particle |
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Definition
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Term
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Definition
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Term
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Definition
-not as easy to handle
-more stable |
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Term
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Definition
-easier to handle
-less stable |
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Term
| particle size analysis techniques |
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Definition
-sieving (method by weight)
-microscopy (method by number)
-light diffraction (method by volume) |
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Term
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Definition
| 50% of particles smaller than this number |
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Term
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Definition
| -mechanical process of reducing the size of particles and aggregates |
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Term
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Definition
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Term
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Definition
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Term
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Definition
-use solvents
-for ointments |
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Term
| pulverization by intervention |
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Definition
-for hard materials
-dissolve in solvent to make finer particles |
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Term
| if you want a more soluble dosage form |
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Definition
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Term
| if you want more stable dosage form |
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Definition
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Term
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Definition
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Term
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Definition
| particle size (INVERSELY) |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
| helium pycnometry measures |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
-particle size/shape
-surface
-density
-statis charge
-moisture
-glidant |
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Term
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Definition
-Carr index
-(Vbulk-Vtap)/Vbulk x 100
-higher the Carr index = lower the flow |
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Term
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Definition
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Term
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Definition
-direct flowability measurement
-pass material thru sieve
-machine records angle
-flatter the cone=better the flow |
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Term
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Definition
-% relative humidity
-P(water)/Psat(water) x 100 |
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Term
| equilibrium moisture content depends on |
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Definition
-humidity/temp
-crystallinity |
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Term
| moisture sorption rate depends on |
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Definition
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Term
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Definition
| to become liquid by absorbing moisture from the air |
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Term
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Definition
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Term
| the bigger the particle size |
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Definition
| the smaller the SA, the better the flow |
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