Term
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Definition
In between a solution and a suspension
Particles larger than molecular dispersions but not large enough to be visible in a light microscope
Very bio-available |
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Term
| What is the size range of the particles for a colloid? |
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Definition
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Term
| Give examples of colloidal system |
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Definition
| Blood, cell membranes, milk, rubber latex, fog |
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Term
| Serum albumin, acacia, and povidone make solutions in water. Why are they considered colloidal? |
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Definition
| The size of individual solute molecules places such solutions in the colloidal range (particle size > 1 nm). |
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Term
| Give some example of colloidal drugs |
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Definition
| Recombinant insulin, interferon, interleukin, and monoclonal antibodies |
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Term
| What can colloidal gold be used for? |
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Definition
A diagnostic agent in nuclear medicine
Dr. Hussain said not tested, but I am cautious |
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Term
| What can 99mTc sulfur be used for? |
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Definition
Liver, spleen and bone scanning
Dr. Hussain said not tested, but I am cautious |
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Term
| When is a colloid lyophillic? |
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Definition
| If there is considerable attraction between the dispersed phase and dispersion medium |
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Term
| When is a colloid hydrophillic? |
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Definition
| If there is considerable attraction between the dispersed phase and dispersion medium, and the dispersion medium is water |
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Term
| When is a colloid lipophillic? |
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Definition
| If there is considerable attraction between the dispersed phase and dispersion medium, and the dispersion medium is oil |
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Term
| Are bentonite, starch, gelatin, and povidone water or oil soluble? |
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Definition
Water
Dr. Hussain said not tested, but I am cautious |
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Term
| Are polystyrene rubber, gum rubber, magnesium sterarate, or aluminium stearate water or oil soluble? |
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Definition
Oil
Dr. Hussain said not tested, but I am cautious |
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Term
| When is a colloid lyophobic? |
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Definition
| If there is little attraction between the dispersed phase and dispersion medium |
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Term
| Define association colloid |
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Definition
| A colloid in which individual molecules are too small to be in the colloidal range, but they tend to associate into larger aggregates when dispersed |
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Term
| Give some examples of molcules that form association colloids |
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Definition
| Surfactant molecules that associate into micelles above the critical micellar concentration (CMC) Phospholipids and liposomes |
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Term
| Define the Faraday-Tyndall effect |
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Definition
The scattering of light by colloids
Can be specific for a specific color |
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Term
| Define Brownian motion as it relates to colloids |
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Definition
| Colloidal particles appear as tiny points of light in constant motion |
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Term
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Definition
| Yes, since colloids are composed of particles that easily adhere to each other to form a surface |
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Term
| Is a colloid electrically charged? |
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Definition
| Yes, colloids undergo electrophoresis by moving to the oppositely charged electrode |
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Term
| List five delivery systems for colloids? |
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Definition
1. Micelles
2. Microemulsions
3. Liposomes
4. Microspheres
5. Nanoparticles |
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Term
| What is the function of a micelle delivery system? |
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Definition
| Micelles are used to solubilize poorly water soluble compounds |
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Term
| Give examples of a colloid that uses a micelle delivery system |
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Definition
Aquamephyton Injection (vitamin K1)
Cernevit-12 for Infusion (mixture of vit. A, D & E).
Dr. Hussain said not tested, but I am cautious |
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Term
| What is the function of a microemulsion delivery system? |
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Definition
| Colloids could be either O/W or W/O microemulsions formulated to be administered via percutaneous, oral or parenteral routes. The advantage of these agents compared to conventional emulsion is their smaller droplet size, which increases drug release, and their superior physical stability. |
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Term
| What is the function of a liposome delivery system? |
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Definition
| Liposomes are used as vehicles to deliver synthetic drugs, polypeptides, proteins including enzymes and antibodies, and nucleic acids. |
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Term
| Give examples of a colloid that uses a liposome delivery system |
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Definition
Ambisome Liposome for Injection (Amphotericin B)
DaunoXome Liposomal Injection (daunorubicin citrate) Doxil Liposomal Injection (doxorubicin HCl)
Dr. Hussain said not tested, but I am cautious |
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Term
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Definition
| Critical micelle concentration, the concentration surfactants that will lead to formation of micelles |
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Term
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Definition
Small insoluble spherical particles consisting of a polymer matrix such as poly lactic-glycolic acid copolymer (PLGA).
Drugs may be physically entrapped in the pores of the microspheres or chemically conjugated to the polymer matrix. |
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Term
| Give examples of a colloid that uses a microsphere delivery system |
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Definition
Lupron Depot for Suspension (leuprolide acetate)
Nutropin Depot for Injectable Suspension (somatropin)
Dr. Hussain said not tested, but I am cautious |
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Term
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Definition
Solid spherical polymeric particles ranging in size from 1-1000 nm (1 μm).
The therapeutic agent is either adsorbed onto the nanoparticles, or encapsulated within them. |
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