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Pharma Sem 2 Part II General Qts
The Re-Quizzenning
44
Pharmacology
Undergraduate 2
09/23/2015

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Term
This is the transporter for the reuptake of ACh
Definition
Theres none
Term
The enzyme that breaks down ACh
Definition
AChE
Term
Deficiency in this leads to memory loss associated with Alzheimer's Disease
Definition
Cholinergic function
Term
The part of the brain that experiences shrinkage in Alzheimer's Disease
Definition
Temporal cortex/frontal lobe
Term
There is a decreased release of this in Alzheimer's Disease
Definition
ACh
Term
Aphasia, apraxia, agnosia, disorientation, and impariment of memory are all symptoms of this disease
Definition
Alzheimer's Disease
Term
Term that refers to a loss of language
Definition
Aphasia
Term
Term that refers to a loss of purposeful movements
Definition
Apraxia
Term
Term that refers to a loss of recognition of objects
Definition
Agnosia
Term
This amino acid transmitter is always excitatory
Definition
Glutamate
Term
This amino acid transmitter is always inhibitory
Definition
GABA
Term
The major excitatory transmitter in the brain
Definition
Glutamate
Term
Glutamate activates these receptors in the brain
Definition
NMDA receptors
Term
When glutamate activates NMDA receptors, it allows the entry of these ions
Definition
Na+ and Ca2+
Term
Current drugs are effective in this percentage of epilepsy patients
Definition
70%
Term
This type of seizure begins locally and remains localised
Definition
Partial seizure
Term
This symptoms of this type of seizure include motor signs, sensory symptoms, and autonomic symptoms
Definition
Simple partial seizure
Term
This symptoms of this type of seizure include impaired consciousness, various clinical manifestations depending on origin and spread
Definition
Complex partial seizure
Term
This symptoms of this type of seizure include strong contractions of musculature and involuntary vocalisations
Definition
Tonic-clonic
Term
This symptoms of this type of seizure include stopping current action and staring blankly, with little or no motor disturbance, abrupt recovery
Definition
Absence/petit-mal
Term
The most common type of epilepsy associated with complex partial seizures
Definition
Temporal lobe epilepsy
Term
This type of seizure involves the whole brain and always a loss of consiousness
Definition
Generalised siezures
Term
Tonic-clonic and absence/petit-mal seizures are subtypes of this form of seizure
Definition
Generalised siezures
Term
This type of seizure is common in children
Definition
Absence/petit-mal
Term
Is acquired or genetic epilepsy more common?
Definition
Acquired
Term
The effect we get from enhancing GABA
Definition
More inhibition
Term
The enzyme that metabolises GABA
Definition
GABA transaminase (GABA-T)
Term
These two types of drugs can bind to other sites on the GABA receptor ti increase inhibition
Definition
Benzodiazepines and barbiturates
Term
Do benzodiazepines and barbiturates modulate or activate the receptor?
Definition
Modulate
Term
The way in which benzodiazepines and barbiturates activate the GABA receptor
Definition
They dont, only enhance
Term
Diazepam and phenobarbitone are examples of this
Definition
GABAa agonists
Term
After one seizure, this percentage of people will have another
Definition
30-50%
Term
The ion that is moving when an AP is starting
Definition
Na
Term
Some epileptic drugs target Na channels on these types of neurons
Definition
Those firing at a high frequency
Term
The term that refers to prolonged and uncontrolled repeated seizures with a high morbidity and mortality
Definition
Status epilepticus
Term
Absence seizures are associated with these types of channels
Definition
T-type Ca2+ channels
Term
Are T-type Ca2+ channels low or high voltage activated?
Definition
Low
Term
T-type Ca2+ channels within this area of the brain provide a "pacemaker" current that produces bursting intrinsic firing leading to absence seizures
Definition
Thalamus
Term
Some (but not the majority) of partial seizures are associated with this type of channel
Definition
High voltage activated (HVA) Ca2+
Term
Gabapentin targets this type of channel
Definition
High voltage activated (HVA) Ca2+
Term
Most anti-epileptic drugs have these as SEs
Definition
Sedation, confusion, skin rashes
Term
The use of this anti-epileptic drug is associated with a narrow safety margin
Definition
Phenytoin
Term
Is a P450 enhancer or inhibitor increase the clearance and decrease the steady state levels of other interacting drugs
Definition
Enhancer
Term
Is a P450 enhancer or inhibitor decrease the clearance and increase the steady state levels of other interacting drugs
Definition
Inhibitor
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