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Pharm
Exam 3
60
Pharmacology
Graduate
11/05/2011

Additional Pharmacology Flashcards

 


 

Cards

Term
Drugs that change cardiac contractility?
Definition
Cardiac inotrophic drugs
Term
Drugs that change cardiac rate?
Definition
Cardiac chronotropic drugs
Term
Drug used for congestive heart failure?
Definition
Digoxin
Term
Digoxin has what clinical responses? (heart rate, contractility, sympathetic tone)
Definition
Decrease HR
Decreases sympathetic tone
Restore baroreceptor function*
Improve contractility
Improve cardiac output
Term
Phase 1
Definition
Early Fast repolarization
Inactivation of Na channels
Term
Phase 2
Definition
Plateau (fast response only)
Inward Ca outward K
Term
Phase 0
Definition
Rapid upstroke
Fast-Na channel on, Na influx
Slow- Calcium influx
Term
Phase 3
Definition
Repolarization
Net outflow of potassium
Term
Phase 4
Definition
Slow response- spontaneous depolarization
Fast response- no spontaneous depolarization
Term
Class 1 antiarrhythmics block what?
Definition
Sodium channels
Term
Class II antiarrhythmics block what?
Definition
Beta 1
Term
Class III antiarrhythmics block what?
Definition
Potassium channels
Term
Class IV antiarrhythmics block what?
Definition
Calcium channels
Term
Class I drugs?
Definition
Quinidine
Procainamide
Lidocaine
Mexiletine
Term
Class II drugs?
Definition
Propanolol
Atenolol
Carvedilol
Sotalol
Term
Class III drug?
Definition
Sotalol
Term
Class IV drugs?
Definition
Diltiazem
Digoxin
Term
Negative ionotropes do what to heart failure?
Definition
Exacerbates it
Term
High afterload results in?
Definition
Poor cardiac output
Term
How to reduce afterload?
Definition
vasodilators
Term
High preload results in?
Definition
Edema formation
Term
ACE inhibition does what to the vessels?
Definition
Maintains vasodilation
Term
Drug that is an ACE inhibitor?
Definition
Enalapril
Term
MAC stands for?
Definition
Minimum alveolar concentration
Term
Factors that MAC of an animal is influenced by?
Definition
Anesthetic premedications
Temp
Age
CO2 levels
Metabolic acidosis
Disease state
Term
MAC for Isoflurane in:
Dog
Horse
Cat
Definition
1.30
1.31
1.63
Term
Used in patients that don't respond to ACE inhibitors or furosemide?
Definition
Hydralazine hydrochloride
Term
Treatment of choice for cats with feline hypertension?
Definition
Amlodipine
Term
Good drug for dogs and cats with thickened myocardium?
Definition
Diltiazem
Term
What is an important physiological parameter that induces renal renin secretion?
Definition
Reduced renal sodium delivery
Term
Adverse reaction to hydralazine?
Definition
Collapse- hypotensive and tachycardia
Term
Used for HYPP and glaucoma patients?
Definition
Acetazolamide
Term
What would administration of an osmotic diuretic do to a dehydrated patient?
Definition
Make it worse!
Term
In loop diuretics where is the resorption of sodium and chloride inhibited?
Definition
Thick portion of Ascending limb of loop of Henle
Term
Inability for concentration and dilutional capacity?
Definition
isosthenuria
Term
Heaves in horses involves what cellular infiltrate and what type of hypersensitivity?
Definition
Neutrophils
III
Term
Asthma in humans and cats has what cellular infiltrate and which type of hypersensitivity?
Definition
Eosinophils
Type I
Term
Should change the Digoxin dose in what breed of dog due to their p-glycoprotein deficiency?
Definition
Collies
Term
Na/K ATPase inhibitor?
Definition
Digoxin
Term
Ionodilator and PDE inhibitor
Definition
Pimobendan
Term
Treatment for boxers with tachyarrhythmias and syncope?
Definition
Sotalol
Term
Which one of the antiarrhythmics is a positive inotrope?
Definition
Digoxin
Term
Treatment for hypertrophic cardiomyopathy in kitties and supraventricular arrhythmias in dogs?
Definition
Diltiazem
Term
Phosphodiesterase III inhibitor, increases cAMP, leading to smooth muscle relaxation?
Definition
Pimobendan
Term
Arteriolar dilator?
Definition
Hydrazaline hydrochloride
Term
Side effect of nitrates such as nitroglycerin?
Definition
Hypotension
Skin rash
Term
Not metabolized or resorbed?
Definition
Mannitol
Term
Anticholinergics are used as preanesthetic agents to treat or prevent?
Definition
Bradycardia
Term
GABA agonist resulting in Cl influx causing hyperpolarization
Anesthetic induction
Definition
Etomidate
Term
Noncompetitively binds to pore of NMDA channel
Definition
Ketamine
Tiletamine
Term
Enhances GABA receptor effects
General anesthetic
Definition
Propofol
Term
Primarily an anticonvulsant
Definition
Phenobarbital (barbiturate)
Term
3 drugs that Bind to benzodiazepine receptors coupled with GABA receptors. Activates Cl- channels and hyperpolarizes the nerve inhibiting neuronal transmission?
Definition
Diazepam
Midazolam
Zolazepam
Term
What are some adverse effects of alpha 2 agonists such as Xylazine, Detomidine?
Definition
Depress GI- colic
Hypoinsilinemia
Pulmonary edema in cattle
Increased intrauterine pressure
Term
Blocks dopamine 2 receptors in the brain
Definition
Acepromazine
Term
4 year old mare with atrial fibrillation?
Definition
Furosemide
Quinidine
Term
23 yo QH with cardiac heart failure?
Definition
Furosemide
Enalapril-ACE inhibitor (vasodilation)
Digoxin- Na/K atpase inhibitor
Term
10 yo DHL cat with sinus tachycardia
Definition
Atenolol- beta blocker
Enalapril- ACE inhibitor
Furosemide- for edema
Term
RAO in horse
Definition
Albuterol or clenbuterol- beta agonist
Atropine- muscarinic antagonist
Dexamethasone
Term
Feline respiratory disease
Definition
Terbutaline- bronchodilation
Prednisone
chronic- flovent and albuterol
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