Term
| What is the prototype for Akylating agents? |
|
Definition
|
|
Term
what is chlorambucil most effective against?
is it cell cycle specific? |
|
Definition
slow growing nonsolid tumors
(chronic leukemia, hodgkins)
non cell cycle specific |
|
|
Term
| What is the prototype for anti metabolites? |
|
Definition
|
|
Term
| Is methotrexate cell cycle specific? |
|
Definition
|
|
Term
What are the additional adverse
effects of methotrexate?
What do we do to limit these? |
|
Definition
Extremely hepato/renal toxic
give in combination |
|
|
Term
What are the usually side effects for
all antineoplastic drugs? |
|
Definition
bone marrow suppression, alopecia,
NVD, epithelial damage |
|
|
Term
| What is the prototype for Antneoplastic antibiotics? |
|
Definition
|
|
Term
| What are additional side effects for doxorubicin? |
|
Definition
|
|
Term
| What is doxorubicin most effective against? |
|
Definition
non solid tumors
(leukemia, bone/breast cancer, kaposis sarcoma)
does not cross blood brain barrier |
|
|
Term
| what is the prototype for mitotic inhibitors? |
|
Definition
|
|
Term
| is vincristine cell cycle specific? |
|
Definition
|
|
Term
what is important to know about vincristine?
what do we do to prevent/aide with this? |
|
Definition
| if it infiltrates will cause severe tissue damage to surrounding area. Wydase is antidote for vincristine to fight infiltration reactions |
|
|
Term
what is the prototype for hormones and
hormone modulators? |
|
Definition
|
|
Term
| What is tamoxifen most effective against? |
|
Definition
breast, ovarian, testicular cancer
(organs that respond to hormones) |
|
|
Term
| What are additional adverse effects of tamoxifen? |
|
Definition
causes menopause like symptoms,
serum calcium levels rise |
|
|
Term
| what is the prototype for cell specific agents? |
|
Definition
|
|
Term
| What is imatinib most effective against? |
|
Definition
| chronic myolegenic leukemia |
|
|
Term
| what are the additional side effects of imatinib? |
|
Definition
renal/hepatic toxic, causes cardiac problem
on the qt interval |
|
|
Term
| what is the prototype for salicylates? |
|
Definition
|
|
Term
| what are aspirins actions? |
|
Definition
anti inflammatory, analgesic,
antipyretic, and anticoagulant |
|
|
Term
| whay shouldnt children be given aspirin? |
|
Definition
| can devlope reyes disease |
|
|
Term
what is the prototype for nsaids?
related agent? |
|
Definition
|
|
Term
| what is tylenols actions? |
|
Definition
|
|
Term
| what is tylenols main asverse effects |
|
Definition
| hepatotoxic, especially with alcohol |
|
|
Term
|
Definition
|
|
Term
| what is ibuprofins actions? |
|
Definition
| antipyretic, analgesic, and +++antiinflamatory+++ |
|
|
Term
| what is the immune suppressants prototype? |
|
Definition
|
|
Term
| what is cyclosporins action |
|
Definition
| anti organ donor rejection |
|
|
