Term
| Properties of an ideal drug |
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Definition
| safe,effective, and selective. Also reversible action, predictability, low cost, and no interactions |
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Term
| Why does renal failure put you at risk for toxicity? |
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Definition
| Drugs are excreted through the urine from the kidney, during failure the duration and intensity of drugs builds up because they are not able to leave the kidneys as quickly. |
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Term
| pre-administration assesment |
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Definition
| Collect baseline data such as vitals and allergies, identify high risk patients such as liver failure pregnancy age and genetic factors, and last assess self-care such as mental status and disabilities |
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Term
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Definition
| Assessment, analysis, planning, implementations, evaluation |
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Term
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Definition
| Highest risk of abuse, Cannibus, hallucinogens and heroin. No prescription use |
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Term
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Definition
| High potential, can lead to dependencies. Barbituarates, opioids, stimulants |
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Term
|
Definition
| Lesser potential, barbituates and steroids. Paregoric |
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Term
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Definition
| Low potential, psychological dependence, benzodiazepines |
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Term
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Definition
| Least potential, small opioid combined with antitussive or antidiarrheal |
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Term
| Parenteral Drug Administration advantages |
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Definition
| Direct delivery of drugs into systemic, 100% bioavailability, immediate effects |
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Term
| Depending on half lifes how should drugs be administered |
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Definition
| Short half life- more frequent administration, long half life- less frequent administration |
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Term
| 3 methods of drug transport across membranes |
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Definition
| Through channels (pores in the bilayer), through a transport system, and direct penetration |
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Term
| Grapefruit juice can inhibit metabolism causing what |
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Definition
|
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Term
|
Definition
| max blood concentration level achieved through absorbtion |
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Term
| Minimum effective concentration |
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Definition
| Plasma drug level below which theraputic effects will not occur |
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Term
|
Definition
| Measure of drugs safety...LD50/ED50 |
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
| A disease produced by a drug. Drug induced. |
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Term
|
Definition
| drug induced birth defect |
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Term
|
Definition
| Uncommon drug response from a genetic predispostion |
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Term
|
Definition
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Term
| Tonic-Clonic Seizure (grand mal) |
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Definition
| Muscle rigidity followed by jerks. Urinate self and also loud cries involved. 90 seconds. |
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Term
| Absence seizure (petit mal) |
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Definition
| Loss of consciousness. 10-30 seconds. Common in children |
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Term
|
Definition
| Loss of muscle tone, sudden collapse |
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Term
|
Definition
| Associated with fever. Tonic-clonic. In children, no risk of epilepsy |
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Term
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Definition
| Movement disorders from antipsychotic drugs. Early-parkinsonism, spasms. Late-tardive, permanent |
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Term
|
Definition
| Particular dose elicits smaller response then initially |
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Term
|
Definition
| Using a drug inconsistantly with medical norm |
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Term
|
Definition
| A abstinence syndrome will occur when use is discontinued |
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Term
|
Definition
| Taking meds that increases levels of serotonin in the body |
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Term
| Lipid solubility and passing through the membrane |
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Definition
| Only lipid soluble drugs can attach to the phosolipid bilayer and pass through |
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Term
| Do all drugs cross placenta |
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Definition
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Term
| Most common cause of adverse reactions in elderly |
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Definition
| Multiple drugs causing interactions |
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Term
| Peripheral nervous system |
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Definition
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Term
|
Definition
| parasympathetic (rest and digest) Sympathetic (fight or flight) |
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Term
| Peripheral nervous system transmitters |
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Definition
| Acetylcholine, norepinephrine, and epinephrine |
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Term
| Parasympathetic nervous system |
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Definition
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Term
| Sympathetic Nervous system |
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Definition
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Term
|
Definition
| Nicotinic N-Stimulates nerves, NicotinicM- contracts muscle, Muscarinic- miosis, bradycardia, bronchi constriction, urination, defecation, erection |
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Term
|
Definition
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Term
|
Definition
| Mydriasis, constricts veins and vessels, ejaculate, contract bladder(hold urine) |
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Term
|
Definition
| Tachycardia, increase renin release |
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Term
|
Definition
| Bronci dilation, relax uterus, glycogenolysis, contract muscle |
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Term
| Muscarinic agonist poisoning is treated with.. |
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Definition
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Term
| Anticholinergic side effects |
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Definition
| Dry mouth, blurred vision, urinary retention, constipation, tachycardia |
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Term
| Alpha blockers are used for.. |
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Definition
| hypertension, and benign prostate hyperplasia |
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Term
| Beta blockers are contraindicated in.. |
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Definition
| asthma patients due to bronchi contriction, and pre-exsisting av block |
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Term
|
Definition
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Term
| Parkinsons disease therapeutic goal |
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Definition
| Imrove ADL's and slow and stabalize course of disease. Help mobility |
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Term
| Most effective drug for parkinsons |
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Definition
| sinemet-combo of levadopa and carbidopa |
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Term
| Common side effects of cholinesterase inhibitors |
|
Definition
| Excessive salivation and secretions, bradycardia, miosis, diarrhea, frequent urination, liver injury, nausea |
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Term
|
Definition
| Cholinesterase inhibitors |
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Term
|
Definition
| Slows decline of function and improves symptoms, very few AE, dizzy headache and confusion |
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Term
|
Definition
| Inflammation and myeline destruction in CNS |
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Term
|
Definition
| Reduce seizures and make a near normal life |
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Term
|
Definition
| Sedation, gum hyperplasia, birth defects |
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Term
|
Definition
| teratogenic, and need to have plasma drug levels monitored |
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Term
| Acetaminophen and alchohol |
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Definition
| Cause liver damage, acute renal failure |
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Term
| Does acetaminophen have anti-inflamm properties |
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Definition
|
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Term
|
Definition
| Unilateral, throbbing, severs, lasts up to 3 days, early morning |
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Term
|
Definition
| Unilateral, peircing, severe, 2 hours, causes eye and ear problems, nighttime, males |
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Term
|
Definition
| Headband effect, squeezing, mild, 7 days, daytime |
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Term
|
Definition
| Artificial sweetner, sodium, chocolate, old cheese and wines, yellow food coloring |
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Term
| First-line drug for migraines |
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Definition
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Term
|
Definition
| Irrational thinking, cant comprehend reality |
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Term
| Anti psychotic drugs treat.. |
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Definition
| Schizophrenia and bipolar disorder |
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Term
| Antidepressants can do what with suicide |
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Definition
|
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Term
| 3 treatments for depression |
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Definition
| Electroconvulsive therapy, psychotherapy, and drugs such as TCA, SSRI, and MAOI |
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Term
|
Definition
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Term
|
Definition
|
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Term
|
Definition
| arythmias, seizure, anticholinergic such as dry mouth |
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Term
| ECT used in major depression why? |
|
Definition
| The benefits develop more rapidly and more effectively |
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Term
| Adverse reactions to benzodiazepines |
|
Definition
| hyperactivity, sleep behavior, amnesia, teratogenic |
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