Term
|
Definition
gemfibrozil (Lopid)
Ind.-lower TG (VLDL), most effective Rx for lowering VLDL
MOA-activate lipoprotein lipase, little effect on LDL |
|
|
Term
| Plant Stanol and Sterol Esters |
|
Definition
| margarine(Benecol), soft spreads(Promise) |
|
|
Term
| Classes that Alter Lipid Levels |
|
Definition
| HMB-CoA Reductase Inhibitors (Statins) Nicotinic acid(Niacin, Vitamin B3) Bile Acid Sequestrants Fibrates Ezetimibe (Zetia) |
|
|
Term
|
Definition
Zetia
Reduces total Chol., LDL, TG, and apolipoproteins, small ^HDL,
MOA- acts Sm. Int. cells, to inhib. chol. absorb,
SE- not severe, rhabdo, hepa, pancreatitis,
Rx inter- +statins=hep damage, + bile=gallstones, +cyclo ^Zetia levels |
|
|
Term
| Nicotine Acid (sustained release form of Niacin) |
|
Definition
Niaspan
very large amounts=flushing, itching
Ind.=red. LDL & TG, ^HDL, take with Statins for most effectiveness,
MOA- inhib. lipolysis of adipose, releases histamine,
SE-flushing, itching, GI, Hepa, Hypergly, gouty arth.
Nursing- low dose ASA, w/ meals, mon. liver lab, |
|
|
Term
| Bile-Acid Sequestrants (3) |
|
Definition
colesevelam (Welchol)-newest, can be given with Statins
cholestyramine, colestipol
MOA-bind bile and prev. reabsorp. causing need to make more from chol.
SE-not systemic, GI
Nursing- encour. fiber, ^fluid int.,
Rx inter.-thiazides, digoxin, warfarin, antibiotics, take 1hr before or 4hrs after |
|
|
Term
| HMB-CoA Reductase Inhibitors- AKA: Statins (2) |
|
Definition
altorvastatin(Lipitor)
simvastin(Zocor) |
|
|
Term
|
Definition
azathioprine(Imuran)
kills B and T cells
Ind.-organ transplant rejection
SE-bone marrow suppression, GI, reduced fertility, neutropenia |
|
|
Term
| Classes of Immunosuppressant Agents (4) |
|
Definition
| Calcineurin Inhibitors Cytotoxic drugs Glucocorticoids Antibodies |
|
|
Term
|
Definition
Muromanab-CD3
RhoGAM (RhIG) |
|
|
Term
| Calcineurin Inhibitors (2) |
|
Definition
|
|
Term
|
Definition
| mod. bacterial endotoxins to form antitoxins (protect against toxins but do not kill bacteria) |
|
|
Term
|
Definition
| admin. of vaccine or toxoid to produce active immunity |
|
|
Term
| Specific immune globulins |
|
Definition
| contain antibodies directed against a specific antigen |
|
|
Term
|
Definition
| preparation containing live attenuated, or killed microorgansims |
|
|
Term
|
Definition
|
|
Term
|
Definition
Rotashield (older caused life threatening bowel disorder)
RotaTeq
Rotarix |
|
|
Term
|
Definition
| aminoglutethimide (not first line treatment and not successful |
|
|
Term
|
Definition
Cortef (Oral)
Solu-Cortef (IV)
has both gluco. and mineral. effects |
|
|
Term
| Glucocorticoid (synthetic steroid) |
|
Definition
|
|
Term
| Glucocorticoid preferred for anti-inflammatory or immunosuppressant, chronic resp. infections |
|
Definition
|
|
Term
| most essential Mineralcorticoid |
|
Definition
|
|
Term
|
Definition
| spironolactone (Aldactone) |
|
|
Term
|
Definition
hydrocortisone (Cortef)
dexamethasone (Decadron)
prednisone (Deltasone) |
|
|
Term
|
Definition
| fludrocortisone (Florinef) |
|
|
Term
| Antidiuretic Hormone (ADH)AKA |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Growth Hormone suppressant |
|
Definition
|
|
Term
| Posterior Pituitary Hormones |
|
Definition
|
|
Term
| Anterior Pituitary Hormones (6) |
|
Definition
GH
Corticotropin-ACTH
Thyrotropin
Follicle Stim. Horm.
Luteinizing Horm.
Prolactin |
|
|
Term
| Dopamine agonists to treat prolactin hyper secretion |
|
Definition
|
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