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Pharm - Tetracyclines
PA School
19
Pharmacology
Graduate
02/13/2010

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Term
indications (4) for tetracyclines:
Definition
1. Resp tract
2. sinus
3. periodontal
4. some STD's
Term
name 3 tetracyclines:
Definition
1. Minocycline
2. Doxycycline
3. Tetracycline
Term
which tetraycycline is used for MRSA?
Definition
Doxycycline
Term
tetracycline area of coverage:
Definition
1. G+
2. G-
3. Anaerobes
4. Atypicals
Term
which other class of abx has the same coverage as tetracyclines?
Definition
macrolides
Term
MOA for tetracyclines:
Definition
30s ribosome
Term
contraindications (2) and caution for tetracyclines:
Definition
contraindicated in <8yo & pregnancy
caution in elderly (dizziness)
Term
when would you give a child <8yo tetracyclines?
Definition
RMSF infection
Term
tetracyclines have decreased absorption when taken with:
Definition
cations & dairy products
Term
tetracycline eliminated by the kidneys:
Definition
tetracycline
Term
tetracycline eliminated through hepatobiliary:
Definition
doxy & minocycline
Term
tetracycline that may cause esophageal ulceration:
Definition
all but esp. minocycline
Term
why no tetracycline before 8yo?
Definition
stains adult teeth
Term
tetracyclines adverse effects:
Definition
1. GI
2. Dizzy
3. Phototox
4. Hepatotox
5. Esoph ulcer
6. skin pigmentation
7. tooth discoloration
Term
3rd generation tetracycline:
Definition
tigecycline
Term
Tigecycline: IV or Oral?
Definition
IV
Term
indications for tigecycline:
Definition
complicated skin and soft tissue infections and intraabd infections.... not first line therapy; for (R) bugs
Term
adverse effects of tigecycline:
Definition
N/V
Term
tetracyclines: are there significant Rx interactions?
Definition
Yes; CYP450
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