Term
|
Definition
| Morphine, Meperidine, Methadone, Fentanyl, Heroin |
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Term
| Strong opiate agonist applied as a patch. Special indications for the patch. |
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Definition
| Fentanyl, onset delayed 12 hrs, do not apply heat to patch - OD! |
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|
Term
| An opiate 100x the potency of morphine. Used for anesthesia. Dur 15-30 min |
|
Definition
| Fentanyl - strong opiate agonist |
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Term
| Methadone - duration and which receptor does it agonize? |
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Definition
|
|
Term
| This opiate dilates the pupil and caused hyperreflexia. Other ADV RXNS: anxiety, tremor, dry mouth, convulsion |
|
Definition
| Meperidine - strong op agonist |
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|
Term
|
Definition
| analgesia, diarrhea, cough, dyspnea of acute pulmonary edema |
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|
Term
| ADV: cerebral/spinal ischemia, resp depression, incr ICP, hypotension. Don´t use in preganancy, emphysema, cor pulmonale, asthma, liver failure |
|
Definition
| morphine - strong op agonist |
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|
Term
| ADV: cerebral/spinal ischemia, resp depression, incr ICP, hypotension. Don´t use in preganancy, emphysema, cor pulmonale, asthma, liver failure |
|
Definition
| morphine - strong op agonist |
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|
Term
| Used as an epidural in post-op or labor, or PO for cancer pt pain. Good for cardiac surgery |
|
Definition
| fentanyl - strong op agonist |
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|
Term
| PO/SQ/IV. Dur 2-4 hours. Converted to active metab in liver. USE: labor/delivery |
|
Definition
| Meperidine - strong op agonist |
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|
Term
| Pre-metab form it is an anti-tussive. Metabolized to morphine (analgesic). |
|
Definition
|
|
Term
| 3 Moderate Opiate Agonists |
|
Definition
| Codeine, Oxycodone, Propoxyphene |
|
|
Term
| Oxycodone is metab in liver to... |
|
Definition
| oxymorphine - mod op agonist |
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|
Term
| Methadone derivative used with acetominophin. |
|
Definition
| Propoxyphene - mod op agonist |
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|
Term
| ADV: toxic doses cause cardiotoxicity not reversed with narcone and pulmonary edema. EtOH and sedatives taken in combo cause resp depression |
|
Definition
| Propoxyphene - moderate op agonist |
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|
Term
| kappa agonist, mu/delta antagonist. Assoc w/ tolerance, dependence, and w/d symptoms |
|
Definition
|
|
Term
| Incr doses cause resp depression, decr GI activity, incr BP/HR, dizziness, hallucinations, and NIGHTMARES |
|
Definition
| Pentazocine - mixed opiate |
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|
Term
| Mu agonist, Kappa antagonist |
|
Definition
|
|
Term
| used for opiate detox administered in-office as sublingual PO. IV for mod-sev pain. |
|
Definition
| Buprenophorine - Mixed opiate |
|
|
Term
| Naloxone has no effect on this mixed opiate |
|
Definition
|
|
Term
| these two drugs, one parenteral adm and the other intranasal adm, have a ceiling effect for resp depression. They have placental transfer. List ADV rxn of both. |
|
Definition
| Nalbuphine (IV/IM/SQ) and Butorphanol (intranasal). ADV: mimic psychosis. (Kappa agon/Mu, Delta antag). |
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|
Term
|
Definition
| Naloxone (NARCAN) and Naltrexone |
|
|
Term
| reverse opiate coma/resp depression within 30 sec of IV adm. |
|
Definition
|
|
Term
PO opiate agonist, dur 48 hrs.
Contraindication, used with what 2 compounds for rapid opiod detox, and what other tx is it used for? |
|
Definition
Dur 48hrs.
+ clonidine/buprenorphine for rapid opiod detox.
Tx: chronic EtOH abuse (benzos better) |
|
|
Term
Two oxicam derivatives used for the tx of RA, AS, OA.
Dose, half life
Which prefers COX II at lower doses? |
|
Definition
Piroxicam, Meloxicam (prefers COX II)
PO, qd, halflife: 30-60 hrs |
|
|
Term
| #1 adv rxn of this NSAID used for the tx of acute gouty arth, AS, OA is gastritis |
|
Definition
|
|
Term
| 2 acetic acid derivatives |
|
Definition
| Indomethacin, Sulindac (less potent) |
|
|
Term
| Antiinfamm and analgesic. C/I in kids. Also treatment of allergic conjuctivitis |
|
Definition
|
|
Term
| 2 proprionic acid derivatives. Use. Focus of each |
|
Definition
Ibuprofen - analgesic.
Naproxen - anti-inflammatory.
USE: RA, OA. |
|
|
Term
| NSAID not to be used with gout, GI ulcers, or coumadin |
|
Definition
|
|
Term
COX II inhib for the tx of RA and OA pain. Less GI bleeding.
Half life and C/Is |
|
Definition
Celocoxib
halflife = 11 hr
don´t use in hepatic/renal dz, sulfa allergy. |
|
|
Term
| This NSAID increases concentration of b-blockers, antidepressants, and neuroleptics |
|
Definition
|
|
Term
| antipyretic and analgesic. Uses: kids w/ viral infetion or chickenpox, GI ulcer pts, gout pts. |
|
Definition
|
|
Term
| antipyretic and analgesic. Uses: kids w/ viral infetion or chickenpox, GI ulcer pts, gout pts. |
|
Definition
|
|
Term
|
Definition
| hepatonecrosis, renal tubule necrosis. |
|
|
Term
DMARD - response time 3-6 wks. 1st line therapy for RA.
C/I? |
|
Definition
Methotrexate - chemical DMARD
C/I in pregnancy or men attempting to impregnate |
|
|
Term
| 4 chemical DMARDS, 3 biogical DMARDS |
|
Definition
CHEM: methotrexate, leflunomide, hydroxychloroguine, sulfalazine
BIO: etanercept (ENBREL), infliximab, anakinra |
|
|
Term
| DMARD also indicated for psoriatic arthritis. ADV: alopecia, hypokalemia. |
|
Definition
| Leflunomide - Chemical DMARD |
|
|
Term
used with methotrexate, decreases TLR on plasmacytoid dendritic cells. Also used for malaria.
Halflife? |
|
Definition
hydroxychoroquine
halflife=2 months |
|
|
Term
used in combo with methotrexate and hydroxychloroquine.
also used to treat IBD |
|
Definition
|
|
Term
ADV: depression in young males,
orange-yellow skin |
|
Definition
|
|
Term
| good DMARD for RA in children |
|
Definition
|
|
Term
| ADV: bronchitis, pneumonia, diarrhea, cellulitis |
|
Definition
|
|
Term
| pancytopenia is ADV rxn of this DMARD |
|
Definition
|
|
Term
| used to treat RA when pt has failed other DMARDS. Interleuken 1 receptor antagonist |
|
Definition
|
|
Term
| This biologic DMARD should not be used in combo with the other biologic DMARDS |
|
Definition
|
|
Term
| alleviates pain assoc with gout in 12 hrs. must be administered 24-48 hrs from onset of attack |
|
Definition
|
|
Term
| used to treat gout from primary and secondary hyperuricemia |
|
Definition
|
|
Term
| Gout DOC for h/o kidney stones or creatinine clearance <50ml/day |
|
Definition
|
|
Term
| NSAID to alleviate pain of acute gout - double the dose on day 2 |
|
Definition
|
|
Term
for gout due to underexcretion. promotes renal clearance of uric acid in proximal tubule.
-used with what to incr absorption |
|
Definition
| Probenecid, Sulfinpyrazone |
|
|
Term
Glucocorticoids for gout treatment.
3 short acting (dur 6 hrs)
2 long acting (dur 12 hrs) - usu for asthma.
#1 PO
#1 SQ |
|
Definition
Short Acting:
Hydrocortisone
Prednisone (#1 PO)
Methylprednisone (#1 SQ)
Long Acting:
dexamethasone
betamethasone |
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