Term
| 3 first gen sulfonylureas: |
|
Definition
1. chlorpropamide
2. tolazamide
3. tolbutamide |
|
|
Term
| 5 second gen sulfonylureas: |
|
Definition
1. glimepiride
2. glipizide
3. glipizide ER
4. Glyburide
5. Micronized Glyburide |
|
|
Term
| list the insulin secretagogs: |
|
Definition
1. SU
2. meglitinide (repaglinide)
3. nateglinide |
|
|
Term
|
Definition
| increase synthesis of proinsulin |
|
|
Term
| insulin secretagogs affect on FGB and %A1c: |
|
Definition
| FBG decrease 60-70 & A1c<1-2% |
|
|
Term
|
Definition
1. increase insulin sensativity of muscle
2. decrease Glu release from liver
3. decrease FA oxidation
4. increase intestinal glu utilizatoin
5. does not increase insulin secretion |
|
|
Term
| metformin's predominant MOA for lowering BG |
|
Definition
| decrease liver Glu release |
|
|
Term
|
Definition
|
|
Term
| name 2 Alpha glucosidase inhibitors: |
|
Definition
|
|
Term
| alpha glucosidase inhibitor MOA: |
|
Definition
| inhibit starch brush border enzymes |
|
|
Term
| name 2 thiazolidinethiones |
|
Definition
1. Rosiglitazone
2. Pioglitazone |
|
|
Term
|
Definition
1. increase syn of GLUT receptors
2. decrease insulin (r)
3. high doses decrease hepatic glu production |
|
|
Term
|
Definition
| GLP-1 agonist: GLP-1 slows gastric emptying and stimulates pancrease to produce insulin in response to a meal |
|
|
Term
|
Definition
1. Januvia
2. Janumet (januvia + metformin) |
|
|
Term
|
Definition
| inhibits GPP-4 which inhibits GLP-1 |
|
|
Term
| 4 contraindications to SU |
|
Definition
1. T1DM
2. DM due to pancreatic resection
3. prego (crosses placenta not teratogenic)
4. significant renal of hepatic dz |
|
|
Term
| 7 contraindications to the use of Metformin |
|
Definition
1. CRE>1.4
2. CHF
3. metabolic acidosis
4. Hx alcohol abuse
5. liver dz
6. septicemia
7. prego/lactation |
|
|
Term
| 6 contraindications to TZD therapy: |
|
Definition
1. class III/IV CHF
2. anemia
3. impaired liver fxn
4. T1DM
5. prego
6. insulin therapy |
|
|
Term
| 4 contraindications to alpha glucosidase inhibitors: |
|
Definition
1. hypersensativity
2. DKA
3. GI issues
4. malabsorption d/o |
|
|
Term
| 2 meds that cause nausea: |
|
Definition
1. sulfonylurea
2. metformin |
|
|
Term
| 2 meds that cause fullness: |
|
Definition
1. SU (dose dependant)
2. metformin |
|
|
Term
| med that causes heartburn |
|
Definition
|
|
Term
| med that causes diarrhea: |
|
Definition
|
|
Term
| 2meds that cause bloating: |
|
Definition
1. metformin
2. aminoglucosidase inhibitors |
|
|
Term
| med causes rash pruritis: |
|
Definition
|
|
Term
| DM oral med causes hypoglycemia: |
|
Definition
| SU (elderly and renally impaired) |
|
|
Term
|
Definition
|
|
Term
| med causes lactic acidosis: |
|
Definition
|
|
Term
| most common predisposing factor in lactic acidosis in metformin use: |
|
Definition
|
|
Term
| med contraindicated in metabolic acidosis: |
|
Definition
|
|
Term
| med causes delay in sucrose efficacy in the tx of hypoglycemia: |
|
Definition
| alphaglucosidase inhibitors |
|
|
Term
| for pts treated with alphaglucosidase inhibitors, hypoglycemia should be treated with: |
|
Definition
|
|
Term
| 2 meds causing increase in transaminases: |
|
Definition
1. TZDs
2. AGIs (>600mg/day) |
|
|
Term
| med causes HF and CHF exacerbations: |
|
Definition
|
|
Term
| med increases the risk of fractures: |
|
Definition
|
|
Term
|
Definition
|
|
Term
| med casuse stuffy runny nose and sore throat |
|
Definition
|
|
Term
| DM med: serious hypersensativity reactions have been reported: |
|
Definition
|
|
Term
| nateglinide: fasting or post-prandial effects? |
|
Definition
|
|
Term
| nateglinide expect A1c to drop: |
|
Definition
|
|
Term
| prefereable med for people who skip meals or have unpredictable schedules: |
|
Definition
|
|
Term
| metformin lowers FBG and A1c% by: |
|
Definition
|
|
Term
| AGIs decrease FBG/PPG & A1c by: |
|
Definition
FBG: 15-30
PPG: 50-60
A1c: 0.5-1.0% |
|
|
Term
| DPP-4 inhibitors drop A1c% by: |
|
Definition
|
|
Term
| secretagogs renally eliminated: |
|
Definition
|
|
Term
| secretagogs eliminates via biliary/feces |
|
Definition
1. 2nd gen SUs
2. nateglinide
3. repaglinide |
|
|
Term
| secretagog that is 100% biliary emliminated: |
|
Definition
|
|
