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Pharm - sleep jenks228
Pharm t5
38
Pharmacology
Graduate
04/05/2010

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Term
4 forms of sleep disorders:
Definition
1. insomnia
2. RLS
3. sleep apnea
4. narcolepsy
Term
4 general etiologies of insomnia:
Definition
1. situational
2. medical
3. psychiatric
4. pharmacologically induced
Term
diagnostic criteria for insomnia:
Definition
1. sx present for >1month
2. epworth sleepiness scale
3. 2wk sleep log
Term
most effective tx for insomnia:
Definition
combined sleep hygiene/behavioral interventions and drug therapy
Term
4 perscription med for insomnia:
Definition
1. BZO hypnotics
2. non-BZO hypnotics
3. sedating antidepressants
4. melatonin agonists
Term
2 OTC for insomnia:
Definition
1. antihistamines
2. melatonin
Term
most commonly prescribed therapy for insomnia:
Definition
BZO hypnotics
Term
6 BZO hypnotics:
Definition
1. triazoLAM
2. EstrazoLAM
3. TemazePAM
4. LorazePAM
5. FlurazePAM
6. QuazePAM
Term
BZO hypnotic MOA
Definition
bind to GABA receptors in CNS
Term
BZO w short T1/2:
Definition
TriazoLAM
Term
2 BZO w long t1/2:
Definition
1. flurazePAM
2. QuazePAM
Term
BZO that causes rebound insomnia:
Definition
triazoLAM
Term
4 adverse effects of BZO:
Definition
1. hangover
2. tolerance
3. amnesia
4. other CNS effects
Term
BZO roles in therapy:
Definition
initiating and maintaining sleep
Term
which BZO only initiates sleep and does not maintain sleep:
Definition
triazolam
Term
use caution w BZOs and:
Definition
1. elderly
2. Hx substance abuse
3. concominant anxiolytic therapy
Term
benefits of non-BZO hypnotics over BZOs:
Definition
1. efficacy comparable w less abuse/tolerance/dependence potential
Term
4 Non-BZO hypnotics:
Definition
1. Zolpidem (ambien)
2. Zolpidem ER
3. Zaleplon (sonata)
4. Eszopiclone (lunesta)
Term
which non-BZO hypnotic has a choice btwn low dose for sleep onset and high dose to maintain sleep?
Definition
Eszopiclone (lunesta)
Term
which effects fo non-BZO lack that BZOs have:
Definition
1. anxiolytic
2. muscle relaxant
3. anticonvulsant properties
Term
4 adverse effects of Non-BZO hypnotics:
Definition
1. dizziness
2. HA
3. amnesia
4. sleep walking
Term
non-BZO used for initiating sleep: 3
Definition
1. zolpidem (ambien)
2. zaleplon (sonata)
3. lunesta
Term
non-BZO that maintain sleep:
Definition
1. ambien cr
2. lunesta
Term
non-BZO: use caution in
Definition
elderly - initiate at lower doses
Term
indications for sedating antidepressants:4
Definition
1. intolerance to BZO/non-BZO
2. Hx of depression
3. neuropathic pain
4. Hx substance abuse
Term
3 sedating antidepressants:
Definition
1. trazedone
2. amitriptyline
3. mirtazepine
Term
sedating AD that causes priapism
Definition
trazedone
Term
name the melatonin receptor agonist:
Definition
Ramelteon
Term
5 adverse effects of MRA ramelteon:
Definition
1. anaphylactic rxns
2. amnesia
3. psychiatric illness/behavior
4. dizziness/fatigue
5. altered testosterone/prolactin
Term
2 OTC meds for sleep:
Definition
1. diphenhydramine
2. doxylamine
Term
4 adverse effects from OTC meds for sleep:
Definition
1. anticholinergic
2. dizziness
3. hangover
4. daytime drowsiness
Term
OTC cause initation or maintenance of sleep?
Definition
initiation
Term
3 meds recommended for pts w hx of substance abuse:
Definition
1. amitrityline
2. trazedone
3. mirtazepine
Term
Avoid these 3 in the elderly:
Definition
1. sedating ADs
2. diphenhydramine
3. long acting BZO
Term
combination recommended for tx failure:
Definition
BZO or BzRA + Sedating AD
Term
2 drugs for the elderly:
Definition
1. BZO
2. BzRA
Term
10 drugs that initiate sleep:
Definition
1. BZOs
2. ambien
3. sonata
4. lunesta
5. trazedone
6. anitriptyline
7. ramelteon
8. diphenhydramine
9. doxylamine
10. melatonin
Term
5 drugs that maintain sleep:
Definition
1. BZO
2. Ambien CR
3. Lunesta
4. trazedone
5. amitriptyline
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